生理学講座 生体調節機能学部門
講座紹介
生理学講座生体調節機能学部門では呼吸の神経機構を中心に多彩なテーマで研究を行っています。動物とヒト(患者を含む)を対象にし、電気生理学や脳イメージングなど多角的なアプローチで進めています。また多岐に渡る診療科の臨床医が大学院生として研究に参加しています。多くの学外研究者との共同研究も積極的に進めており、出身分野を問わず若手研究者の育成に取り組んでおります。大学院 医学研究科長
医学部 生理学講座生体調節機能学部門
教授 泉崎雅彦
摘出脳幹-脊髄標本を用いた各種中枢神経機構の研究
1. 呼吸リズム形成の神経機構の解明主に、ラット(またはマウス)の摘出脳幹-脊髄標本において、電気生理学的方法、光学的測定法などを用いて、呼吸リズム形成の神経機構を明らかにする研究を行っています。転写因子Phox2bが呼吸リズムジェネレーターである傍顔面神経呼吸ニューロングループ(pFRG)の特異的マーカーであることを明らかにしました。Phox2b発現ニューロンが光感受性チャネルの一種であるチャネルロドプシン2を発現するラットを作成し、呼吸中枢の局所ネットワーク解析,二酸化炭素受容および低酸素受容機構などを解析しています。
2. 交感神経活動の調節機構の解析
視床下部、延髄及び脊髄交感神経系中枢の神経機構の解析を行っています。
3. 呼吸筋収縮力の調節機構の解明
呼吸は横隔膜や肋間筋など多くの筋が適切に収縮することにより肺を換気しています。この筋収縮力の調節に関わる脊髄介在ニューロンの解析を行っています。
4. 呼吸と歩行の協調機構の解明
肋間筋や腹壁筋など体幹を支える筋は呼吸や歩行、姿勢制御など複数の役割を持っています。呼吸中枢や歩行中枢によるこれらの筋収縮力の調節機構を解析しています。
5. 吸啜、嚥下の神経機構の解明
我々は孤束核にあるPhox2b発現ニューロンが吸啜および嚥下のリズム形成に重要な役割を果たしていることを明らかにしました。吸啜、嚥下に関与する脳幹内ネットワークの解析を行っています。
ヒトの呼吸、情動、嗅覚の連関性の解明 —脳形態?機能画像解析を用いて?
呼吸は情動と嗅覚に深く関連しています。その連関性を磁気共鳴画像(MRI)、機能的磁気共鳴画像(fMRI)、脳波、光トポグラフィー(NIRS)の脳画像解析を用いて研究を進めています。現在3つのプロジェクトが進行しています。1. コミュニケーションとしての呼吸
情動の変化は呼吸の変化として表れます。またヒトの情動に共感して呼吸パターンが他者と同調することを報告してきました。呼吸の社会相互作用、呼吸のコミュニケーションを課題に工学、心理学、医学、芸術など他分野と連携し研究を進めています。
2. 呼吸と嗅覚の連関性の研究
嗅覚は呼吸と深く関連しています。その連関性をfMRIを用いて活動部位の同定、活動部位間の接続性から検証しています。特に香りによる自伝的記憶の想起を課題に産学連携体制で研究を進めています。嗅覚は記憶とのつながりが深いため、嗅覚障害は記憶、認知の低下を示すことを報告してきました。嗅覚障害を初期症状とする認知症、パーキンソン病の脳機能、形態の異常を嗅覚低下から予測し得るスクリーニング法を目指し、現在昭和大学神経内科と共同研究を進めています。また近年、嗅覚と記憶について動物実験とヒトの実験を平行して行い、嗅覚刺激における海馬の神経再生の促進と速度を検証し、嗅覚刺激による脳機能トレーニング法の創出を目指しています。
3. 安静時呼吸と脳活動の研究
呼吸は延髄でリズムが形成されているが、情動によっても変化し、また随意的にも変化します。これまで呼吸を変化させることで情動をコントロールできることを示してきました。MRI下で呼吸、心拍、体内CO2濃度を同時記録するシステムを確立し、安静時fMRIへの生理ノイズの影響を検証するとともに、脳内の活動と呼吸パターン、情動のつながりを検証しています。
中枢神経系リハビリテーションに関する研究
脳卒中をはじめとする中枢神経損傷患者は、運動、感覚、認知機能などの障害が残存しADLとQOLを大きく低下させます。これらの機能障害に対して、リハビリテーションを行うことで機能回復に結びつくことが分かってきました。しかし、リハビリテーションの効果や効果的なリハビリテーションの手法等、未だ不明点が多くあります。そこで、中枢神経損傷モデルマウスを作製し、リハビリテーションの効果について、生理学的、運動学的、組織学的、そして分子生物学的手法を用いることで研究を進めています。講座員
教員(専任)
役職 | 氏名 | name |
---|---|---|
教授 | 泉﨑 雅彦 | Izumizaki Masahiko |
准教授 | 飯塚 眞喜人 | Iizuka Makito |
准教授 | 政岡 ゆり | Masaoka Yuri |
講師 | 本間 元康 | Honma Motoyasu |
助教 | 内田 有希 | Uchida Yuki |
助教 | 森谷 梨加 | Moriya Rika |
教員(兼任)
役職 | 氏名 | name |
---|---|---|
名誉教授 | 本間 生夫 | Homma Ikuo |
兼担教授 | 金丸 みつ子(富士吉田教育部) | Kanamaru Mitsuko |
兼担准教授 | 仲保 徹(保健医療学部) | Nakabo Toru |
客員教授 | 鬼丸 洋 | Onimaru Hiroshi |
客員教授 | 渋谷 まさと | Shibuya Masato |
兼担講師 | 吉川 輝(保健医療学部) | Yoshikawa Akira |
兼任講師 | 河合 章 | Kawai Akira |
兼任講師 | 山田 峰彦(併任、藤が丘病院呼吸器内科) | Yamada Minehiko |
兼任講師 | 荒田 晶子 | Arata Akiko |
兼任講師 | 飯ヶ谷 嘉門 | Iigaya Kamon |
兼任講師 | 箕浦 慶乃 | Minoura Yoshino |
研究業績
すべて開く +
2023年業績
Oshima N, Onimaru H, Yamashiro A, Goto H, Tanoue K, Fukunaga T, Sato H, Uto A, Matsubara H, Imakiire T, Kumagai H. SGLT2 and SGLT1 inhibitors suppress the activities of the RVLM neurons in newborn Wistar rats. Hypertens Res. 2024 Jan;47(1):46-54.
Tsuzawa K, Onimaru H, Inagaki K, Izumizaki M. Involvement of cannabinoid receptors in depression of the putative nociceptive response in spinal cord preparations isolated from neonatal rats. J Physiol Sci. 2023 Oct 6;73(1):23.
Yoshikawa A, Iizuka M, Kanamaru M, Kamijo S, Ohtaki H, Izumizaki M .Exercise evaluation with metabolic and ventilatory responses and blood lactate concentration in mice. Respir Physiol Neurobiol. 2023 Dec;318:104163.
Yoda S, Onimaru H, Izumizaki M. Effects of aconitine on the respiratory activity of brainstem-spinal cord preparations isolated from newborn rats.
Pflugers Arch. 2023 Nov;475(11):1301-1314.
Onimaru H, Fukushi I, Ikeda K, Yazawa I, Takeda K, Okada Y, Izumizaki M. Cell Responses of the Ventrolateral Medulla to PAR1 Activation and Changes in Respiratory Rhythm in Newborn Rat En Bloc Brainstem-Spinal Cord Preparations. Neuroscience. 2023 Sep 15;528:89-101.
Takamiya S, Honma M, Masaoka Y, Okada M, Ohashi S, Tanaka Y, Suzuki K, Uematsu S, Kitami A, Izumizaki M. Preoperative state anxiety predicts postoperative health-related quality of life: A prospective observational study on patients undergoing lung cancer surgery. Front Psychol. 2023 Apr 11;14:1161333.
Moriya R, Hokari S, Ohshima Y, Suzuki R, Nagai A, Fujito N, Takahashi A, Aoki N, Watanabe S, Koya T, Nakayama H, Izumizaki M, Kikuchi T. Continuous positive airway pressure treatment reduces renal tubular damage in patients with obstructive sleep apnea: A retrospective single-center cohort study. Sleep Med. 2023 Jun;106:106-115.
Uchida Y, Izumizaki M. Modulation of acyl and des-acyl ghrelin on autonomic and behavioral thermoregulation in various ambient temperatures. J Therm Biol. 2023 Apr;113:103543.
Lin ST, Iizuka M, Mikami Y, Yoda S, Onimaru H, Izumizaki M. Cannabinoid receptors involved in descending inhibition on spinal seizure-like activity in the phrenic output. Biomed Res. 2023;44(2):41-49.
Sakikawa K, Masaoka Y, Honma M, Yoshikawa A, Yoshida M, Kamimura S, Ida M, Kobayashi H, Izumizaki M. Role of the amygdala-medial orbitofrontal relationship in odor recognition in the elderly. Brain Behav. 2023 Apr;13(4):e2956.
Kuroda T, Ono K, Honma M, Asano M, Mori Y, Futamura A, Yano S, Kanemoto M, Hieda S, Baba Y, Izumizaki M, Murakami H. Cerebral white matter lesions and regional blood flow are associated with reduced cognitive function in early-stage cognitive impairment. Front Aging Neurosci. 2023 Feb 16;15:1126618.
Kosuge M, Honma M, Masaoka Y, Kosuge S, Nakayama M, Kamijo S, Shikama Y, Izumizaki M. Respiratory rhythm affects recalibration of body ownership. Sci Rep. 2023 Jan 17;13(1):920.
Yoshikawa A, Ohtaki H, Miyamoto K, Kim S, Hase K, Yoshida M, Kamijo S, Kamimura S, Koiwa N, Izumizaki M. Mild-intensity running exercise recovered motor function by improvement of ankle mobility after unilateral brain injury of mice using three-dimensional kinematic analysis techniques. Brain Res. 2023 Jan 1;1798:148160.
Ota S, Onimaru H, Izumizaki M. Effect of cisplatin on respiratory activity in neonatal rats.
Pflugers Arch. 2023 Feb;475(2):233-248.
Yoshiike T, Benedetti F, Moriguchi Y, Vai B, Aggio V, Asano K, Ito M, Ikeda H, Ohmura H, Honma M, Yamada N, Kim Y, Nakajima S, Kuriyama K. Exploring the role of empathy in prolonged grief reactions to bereavement. Sci Rep. 2023 May 10;13(1):7596.
Honma M, Sasaki F, Kamo H, Nuermaimaiti M, Kujirai H, Atsumi T, Umemura A, Iwamuro H, Shimo Y, Oyama G, Hattori N, Terao Y. Role of the subthalamic nucleus in perceiving and estimating the passage of time. Front Aging Neurosci. 2023 Mar 2;15:1090052.
Tsuzawa K, Onimaru H, Inagaki K, Izumizaki M. Involvement of cannabinoid receptors in depression of the putative nociceptive response in spinal cord preparations isolated from neonatal rats. J Physiol Sci. 2023 Oct 6;73(1):23.
Yoshikawa A, Iizuka M, Kanamaru M, Kamijo S, Ohtaki H, Izumizaki M .Exercise evaluation with metabolic and ventilatory responses and blood lactate concentration in mice. Respir Physiol Neurobiol. 2023 Dec;318:104163.
Yoda S, Onimaru H, Izumizaki M. Effects of aconitine on the respiratory activity of brainstem-spinal cord preparations isolated from newborn rats.
Pflugers Arch. 2023 Nov;475(11):1301-1314.
Onimaru H, Fukushi I, Ikeda K, Yazawa I, Takeda K, Okada Y, Izumizaki M. Cell Responses of the Ventrolateral Medulla to PAR1 Activation and Changes in Respiratory Rhythm in Newborn Rat En Bloc Brainstem-Spinal Cord Preparations. Neuroscience. 2023 Sep 15;528:89-101.
Takamiya S, Honma M, Masaoka Y, Okada M, Ohashi S, Tanaka Y, Suzuki K, Uematsu S, Kitami A, Izumizaki M. Preoperative state anxiety predicts postoperative health-related quality of life: A prospective observational study on patients undergoing lung cancer surgery. Front Psychol. 2023 Apr 11;14:1161333.
Moriya R, Hokari S, Ohshima Y, Suzuki R, Nagai A, Fujito N, Takahashi A, Aoki N, Watanabe S, Koya T, Nakayama H, Izumizaki M, Kikuchi T. Continuous positive airway pressure treatment reduces renal tubular damage in patients with obstructive sleep apnea: A retrospective single-center cohort study. Sleep Med. 2023 Jun;106:106-115.
Uchida Y, Izumizaki M. Modulation of acyl and des-acyl ghrelin on autonomic and behavioral thermoregulation in various ambient temperatures. J Therm Biol. 2023 Apr;113:103543.
Lin ST, Iizuka M, Mikami Y, Yoda S, Onimaru H, Izumizaki M. Cannabinoid receptors involved in descending inhibition on spinal seizure-like activity in the phrenic output. Biomed Res. 2023;44(2):41-49.
Sakikawa K, Masaoka Y, Honma M, Yoshikawa A, Yoshida M, Kamimura S, Ida M, Kobayashi H, Izumizaki M. Role of the amygdala-medial orbitofrontal relationship in odor recognition in the elderly. Brain Behav. 2023 Apr;13(4):e2956.
Kuroda T, Ono K, Honma M, Asano M, Mori Y, Futamura A, Yano S, Kanemoto M, Hieda S, Baba Y, Izumizaki M, Murakami H. Cerebral white matter lesions and regional blood flow are associated with reduced cognitive function in early-stage cognitive impairment. Front Aging Neurosci. 2023 Feb 16;15:1126618.
Kosuge M, Honma M, Masaoka Y, Kosuge S, Nakayama M, Kamijo S, Shikama Y, Izumizaki M. Respiratory rhythm affects recalibration of body ownership. Sci Rep. 2023 Jan 17;13(1):920.
Yoshikawa A, Ohtaki H, Miyamoto K, Kim S, Hase K, Yoshida M, Kamijo S, Kamimura S, Koiwa N, Izumizaki M. Mild-intensity running exercise recovered motor function by improvement of ankle mobility after unilateral brain injury of mice using three-dimensional kinematic analysis techniques. Brain Res. 2023 Jan 1;1798:148160.
Ota S, Onimaru H, Izumizaki M. Effect of cisplatin on respiratory activity in neonatal rats.
Pflugers Arch. 2023 Feb;475(2):233-248.
Yoshiike T, Benedetti F, Moriguchi Y, Vai B, Aggio V, Asano K, Ito M, Ikeda H, Ohmura H, Honma M, Yamada N, Kim Y, Nakajima S, Kuriyama K. Exploring the role of empathy in prolonged grief reactions to bereavement. Sci Rep. 2023 May 10;13(1):7596.
Honma M, Sasaki F, Kamo H, Nuermaimaiti M, Kujirai H, Atsumi T, Umemura A, Iwamuro H, Shimo Y, Oyama G, Hattori N, Terao Y. Role of the subthalamic nucleus in perceiving and estimating the passage of time. Front Aging Neurosci. 2023 Mar 2;15:1090052.
2022年業績
Ota S, Sugawa S, Suematsu E, Shinoda M, Izumizaki M, Shinkai M. Possibility of underestimation of COVID-19 prevalence by PCR and serological tests. J Microbiol Immunol Infect. 2022 Dec;55(6 Pt 1):1076-1083.
Fukushi I, Yokota S, Takeda K, Terada J, Umeda A, Yoshizawa M, Kono Y, Hasebe Y, Onimaru H, Pokorski M, Okada Y. Dual orexin receptor blocker suvorexant attenuates hypercapnic ventilatory augmentation in mice. Brain Res. 2022 Nov 15;1795:148061.
Mikami Y, Iizuka M, Onimaru H, Izumizaki M. Glycine and GABAA receptors suppressively regulate the inspiratory-related calcium rise in the thoracic inspiratory cells of the neonatal rat. J Physiol Sci. 2022 Oct 3;72(1):24.
Kamimura S, Masaoka Y, Yoshikawa A, Kamijo S, Ohtaki H, Koiwa N, Honma M, Sakikawa K, Kobayashi H, Izumizaki M. New granule cells in the olfactory bulb are associated with high respiratory input in an enriched odor environment. Neurosci Res. 2022 Sep;182:52-59.
Uchida Y, Izumizaki M. The use of wearable devices for predicting biphasic basal body temperature to estimate the date of ovulation in women. J Therm Biol. 2022 Aug;108:103290.
Honma M, Saito S, Atsumi T, Tokushige SI, Inomata-Terada S, Chiba A, Terao Y. Inducing Cortical Plasticity to Manipulate and Consolidate Subjective Time Interval Production. Neuromodulation. 2022 Jun;25(4):511-519.
Kajiwara R, Nakamura S, Ikeda K, Onimaru H, Yoshida A, Tsutsumi Y, Nakayama K, Mochizuki A, Dantsuji M, Nishimura A, Tachikawa S, Iijima T, Inoue T. Intrinsic properties and synaptic connectivity of Phox2b-expressing neurons in rat rostral parvocellular reticular formation. Neurosci Res. 2022 May;178:41-51.
Yoshida Y, Azuma M, Furukawa K, Mizuno K, Den H, Kamiya T, Izumizaki M. Microwave Heating of Human Milk With Direct Temperature Monitoring. J Hum Lact. 2022 May;38(2):323-331.
Matsuno S, Yoshimura A, Yoshiike T, Morita S, Fujii Y, Honma M, Ozeki Y, Kuriyama K. Toe grip force of the dominant foot is associated with fall risk in community-dwelling older adults: a cross-sectional study. J Foot Ankle Res. 2022 May 30;15(1):42.
Shibata K, Wakabayashi K, Ishinaga T, Morimura M, Aizawa N, Suzuki T, Furuya T, Sato C, Nishikura T, Ikeda N, Kikuchi M, Tanno K, Shinke T, Izumizaki M. Feasibility, Safety, and Long-Term Outcomes of Zero-Contrast Percutaneous Coronary Intervention in Patients With Chronic Kidney Disease. Circ J. 2022 Apr 25;86(5):787-796.
Katsuki S, Ota S, Yoda S, Onimaru H, Dohi K, Izumizaki M. Effects of ANP and BNP on the generation of respiratory rhythms in brainstem-spinal cord preparation isolated from newborn rats. Biomed Res. 2022;43(4):127-135.
Barioni NO, Derakhshan F, Tenorio Lopes L, Onimaru H, Roy A, McDonald F, Scheibli E, Baghdadwala MI, Heidari N, Bharadia M, Ikeda K, Yazawa I, Okada Y, Harris MB, Dutschmann M, Wilson RJA. Novel oxygen sensing mechanism in the spinal cord involved in cardiorespiratory responses to hypoxia. Sci Adv. 2022 Mar 25;8(12):eabm1444.
Yazawa I, Okazaki S, Yokota S, Takeda K, Fukushi I, Yoshizawa M, Onimaru H, Okada Y. Coherence analysis of the calcium activity of putative astrocytic and neuronal cells on the L5 ventral horn and neural output in activated lumbar CPG networks. Neurosci Lett. 2022 Feb 6;771:136421.
Honma M, Masaoka Y, Iizuka N, Wada S, Kamimura S, Yoshikawa A, Moriya R, Kamijo S, Izumizaki M. Reading on a smartphone affects sigh generation, brain activity, and comprehension. Sci Rep. 2022 Jan 31;12(1):1589.
Iizuka M, Ruangkittisakul A, Ballanyi K. Expiratory abdominal muscle nerve is active at flexor phase, while inspiratory phrenic nerve is not active during locomotion evoked by 5-HT and NMDA in the neonatal rat. Neurosci Res. 2022 Jan;174:9-18.
Fukushi I, Yokota S, Takeda K, Terada J, Umeda A, Yoshizawa M, Kono Y, Hasebe Y, Onimaru H, Pokorski M, Okada Y. Dual orexin receptor blocker suvorexant attenuates hypercapnic ventilatory augmentation in mice. Brain Res. 2022 Nov 15;1795:148061.
Mikami Y, Iizuka M, Onimaru H, Izumizaki M. Glycine and GABAA receptors suppressively regulate the inspiratory-related calcium rise in the thoracic inspiratory cells of the neonatal rat. J Physiol Sci. 2022 Oct 3;72(1):24.
Kamimura S, Masaoka Y, Yoshikawa A, Kamijo S, Ohtaki H, Koiwa N, Honma M, Sakikawa K, Kobayashi H, Izumizaki M. New granule cells in the olfactory bulb are associated with high respiratory input in an enriched odor environment. Neurosci Res. 2022 Sep;182:52-59.
Uchida Y, Izumizaki M. The use of wearable devices for predicting biphasic basal body temperature to estimate the date of ovulation in women. J Therm Biol. 2022 Aug;108:103290.
Honma M, Saito S, Atsumi T, Tokushige SI, Inomata-Terada S, Chiba A, Terao Y. Inducing Cortical Plasticity to Manipulate and Consolidate Subjective Time Interval Production. Neuromodulation. 2022 Jun;25(4):511-519.
Kajiwara R, Nakamura S, Ikeda K, Onimaru H, Yoshida A, Tsutsumi Y, Nakayama K, Mochizuki A, Dantsuji M, Nishimura A, Tachikawa S, Iijima T, Inoue T. Intrinsic properties and synaptic connectivity of Phox2b-expressing neurons in rat rostral parvocellular reticular formation. Neurosci Res. 2022 May;178:41-51.
Yoshida Y, Azuma M, Furukawa K, Mizuno K, Den H, Kamiya T, Izumizaki M. Microwave Heating of Human Milk With Direct Temperature Monitoring. J Hum Lact. 2022 May;38(2):323-331.
Matsuno S, Yoshimura A, Yoshiike T, Morita S, Fujii Y, Honma M, Ozeki Y, Kuriyama K. Toe grip force of the dominant foot is associated with fall risk in community-dwelling older adults: a cross-sectional study. J Foot Ankle Res. 2022 May 30;15(1):42.
Shibata K, Wakabayashi K, Ishinaga T, Morimura M, Aizawa N, Suzuki T, Furuya T, Sato C, Nishikura T, Ikeda N, Kikuchi M, Tanno K, Shinke T, Izumizaki M. Feasibility, Safety, and Long-Term Outcomes of Zero-Contrast Percutaneous Coronary Intervention in Patients With Chronic Kidney Disease. Circ J. 2022 Apr 25;86(5):787-796.
Katsuki S, Ota S, Yoda S, Onimaru H, Dohi K, Izumizaki M. Effects of ANP and BNP on the generation of respiratory rhythms in brainstem-spinal cord preparation isolated from newborn rats. Biomed Res. 2022;43(4):127-135.
Barioni NO, Derakhshan F, Tenorio Lopes L, Onimaru H, Roy A, McDonald F, Scheibli E, Baghdadwala MI, Heidari N, Bharadia M, Ikeda K, Yazawa I, Okada Y, Harris MB, Dutschmann M, Wilson RJA. Novel oxygen sensing mechanism in the spinal cord involved in cardiorespiratory responses to hypoxia. Sci Adv. 2022 Mar 25;8(12):eabm1444.
Yazawa I, Okazaki S, Yokota S, Takeda K, Fukushi I, Yoshizawa M, Onimaru H, Okada Y. Coherence analysis of the calcium activity of putative astrocytic and neuronal cells on the L5 ventral horn and neural output in activated lumbar CPG networks. Neurosci Lett. 2022 Feb 6;771:136421.
Honma M, Masaoka Y, Iizuka N, Wada S, Kamimura S, Yoshikawa A, Moriya R, Kamijo S, Izumizaki M. Reading on a smartphone affects sigh generation, brain activity, and comprehension. Sci Rep. 2022 Jan 31;12(1):1589.
Iizuka M, Ruangkittisakul A, Ballanyi K. Expiratory abdominal muscle nerve is active at flexor phase, while inspiratory phrenic nerve is not active during locomotion evoked by 5-HT and NMDA in the neonatal rat. Neurosci Res. 2022 Jan;174:9-18.
2021年業績
Kokudai Y, Honma M, Masaoka Y, Yoshida M, Sugiyama H, Yoshikawa A, Koiwa N, Kubota S, Iizuka N, Wada S, Kamijo S, Uchida Y, Yano S, Ida M, Ono K, Izumizaki M. Cascade process mediated by left hippocampus and left superior frontal gyrus affects relationship
between aging and cognitive dysfunction. BMC Neurosci. 2021 Dec 7;22(1):75.
Kajiwara R, Nakamura S, Ikeda K, Onimaru H, Yoshida A, Tsutsumi Y, Nakayama K, Mochizuki A, Dantsuji M, Nishimura A, Tachikawa S, Iijima T, Inoue T. Intrinsic properties and synaptic connectivity of Phox2b-expressing neurons in rat rostral parvocellular reticular formation. Neurosci Res. 2021 Dec 29:S0168-0102(21)00265-0.
Yazawa I, Okazaki S, Yokota S, Takeda K, Fukushi I, Yoshizawa M, Onimaru H, Okada Y. Coherence analysis of the calcium activity of putative astrocytic and neuronal cells on the L5 ventral horn and neural output in activated lumbar CPG networks. Neurosci Lett. 2021 Dec 27;771:136421.
Yoshida Y, Azuma M, Kuwabara H, Miyazawa T, Nakano Y, Furukawa K, Hawthorne KM, Izumizaki M, Takaki T, Sakaue M, Mizuno K. Human milk-based fortifier is associated with less alteration of milk fat globule size than cow milk-based fortifier. PLoS One. 2021 Dec 7;16(12):e0257491.
Moriya R, Kanamaru M, Okuma N, Yoshikawa A, Tanaka KF, Hokari S, Ohshima Y, Yamanaka A, Honma M, Onimaru H, Kikuchi T, Izumizaki M. Optogenetic activation of DRN 5-HT neurons induced active wakefulness, not quiet wakefulness. Brain Res Bull. 2021 Dec;177:129-142.
Katsuki S, Ikeda K, Onimaru H, Dohi K, Izumizaki M. Effects of acetylcholine on hypoglossal and C4 nerve activity in brainstem-spinal cord preparations from newborn rat. Respir Physiol Neurobiol. 2021 Nov;293:103737.
Fukushi I, Takeda K, Pokorski M, Kono Y, Yoshizawa M, Hasebe Y, Nakao A, Mori Y, Onimaru H, Okada Y. Activation of Astrocytes in the Persistence of Post-hypoxic Respiratory Augmentation. Front Physiol. 2021 Oct 8;12:757731.
Yoshida Y, Azuma M, Furukawa K, Mizuno K, Den H, Kamiya T, Izumizaki M. Microwave Heating of Human Milk With Direct Temperature Monitoring. J Hum Lact. 2021 Oct 27:8903344211047452.
Ota S, Sugawa S, Suematsu E, Shinoda M, Izumizaki M, Shinkai M. Possibility of underestimation of COVID-19 prevalence by PCR and serological tests. J Microbiol Immunol Infect. 2021 Sep 29:S1684-1182(21)00192-4.
Masaoka Y, Sugiyama H, Yoshida M, Yoshikawa A, Honma M, Koiwa N, Kamijo S, Watanabe K, Kubota S, Iizuka N, Ida M, Ono K, Izumizaki M. Odors Associated With Autobiographical Memory Induce Visual Imagination of Emotional Scenes as Well as Orbitofrontal-Fusiform Activation. Front Neurosci. 2021 Aug 3;15:709050.
Uchida Y, Izumizaki M. Effect of menstrual cycle and female hormones on TRP and TREK channels in modifying thermosensitivity and physiological functions in women. J Therm Biol. 2021 Aug;100:103029.
Wada S, Honma M, Masaoka Y, Yoshida M, Koiwa N, Sugiyama H, Iizuka N, Kubota S, Kokudai Y, Yoshikawa A, Kamijo S, Kamimura S, Ida M, Ono K, Onda H, Izumizaki M. Volume of the right supramarginal gyrus is associated with a maintenance of emotion recognition ability. PLoS One. 2021 Jul 22;16(7):e0254623.
Honma M, Murakami H, Yabe Y, Kuroda T, Futamura A, Sugimoto A, Terao Y, Masaoka Y, Izumizaki M, Kawamura M, Ono K. Stopwatch training improves cognitive functions in patients with Parkinson's disease. J Neurosci Res. 2021 May;99(5):1325-1336.
Iizuka N, Masaoka Y, Kubota S, Sugiyama H, Yoshida M, Yoshikawa A, Koiwa N, Honma M, Watanabe K, Kamijo S, Kamimura S, Ida M, Ono K, Izumizaki M. Entorhinal cortex and parahippocampus volume reductions impact olfactory decline in aged subjects. Brain Behav. 2021 May;11(5):e02115.
Uchida Y, Sato I, Atsumi K, Tsunekawa C. UCP1 and TRPM8 expression in the brown fat did not affect the restriction of menthol-induced hyperthermia by estradiol in ovariectomized rats. J Nutr Sci Vitaminol. 2021 May 67(2);130-134.
Onimaru H, Yazawa I, Takeda K, Fukushi I, Okada Y. Calcium Imaging Analysis of Cellular Responses to Hypercapnia and Hypoxia in the NTS of Newborn Rat Brainstem Preparation. Front Physiol. 2021 Mar 25;12:645904.
Terao Y, Honma M, Asahara Y, Tokushige SI, Furubayashi T, Miyazaki T, Inomata-Terada S, Uchibori A, Miyagawa S, Ichikawa Y, Chiba A, Ugawa Y, Suzuki M. Time Distortion in Parkinsonism. Front Neurosci. 2021 Mar 19;15:648814.
Matsuno S, Yoshiike T, Yoshimura A, Morita S, Fujii Y, Honma M, Ozeki Y, Kuriyama K. Contribution of Somatosensory and Parietal Association Areas in Improving Standing Postural Stability Through Standing Plantar Perception Training in Community-Dwelling Older Adults. J Aging Phys Act. 2021 Feb 10;29(5):761-770.
Onimaru H, Ikeda K. Optogenetic Approach to Local Neuron Network Analysis of the Medullary Respiratory Center. Adv Exp Med Biol. 2021;1293:449-458.
Kajiwara R, Nakamura S, Ikeda K, Onimaru H, Yoshida A, Tsutsumi Y, Nakayama K, Mochizuki A, Dantsuji M, Nishimura A, Tachikawa S, Iijima T, Inoue T. Intrinsic properties and synaptic connectivity of Phox2b-expressing neurons in rat rostral parvocellular reticular formation. Neurosci Res. 2021 Dec 29:S0168-0102(21)00265-0.
Yazawa I, Okazaki S, Yokota S, Takeda K, Fukushi I, Yoshizawa M, Onimaru H, Okada Y. Coherence analysis of the calcium activity of putative astrocytic and neuronal cells on the L5 ventral horn and neural output in activated lumbar CPG networks. Neurosci Lett. 2021 Dec 27;771:136421.
Yoshida Y, Azuma M, Kuwabara H, Miyazawa T, Nakano Y, Furukawa K, Hawthorne KM, Izumizaki M, Takaki T, Sakaue M, Mizuno K. Human milk-based fortifier is associated with less alteration of milk fat globule size than cow milk-based fortifier. PLoS One. 2021 Dec 7;16(12):e0257491.
Moriya R, Kanamaru M, Okuma N, Yoshikawa A, Tanaka KF, Hokari S, Ohshima Y, Yamanaka A, Honma M, Onimaru H, Kikuchi T, Izumizaki M. Optogenetic activation of DRN 5-HT neurons induced active wakefulness, not quiet wakefulness. Brain Res Bull. 2021 Dec;177:129-142.
Katsuki S, Ikeda K, Onimaru H, Dohi K, Izumizaki M. Effects of acetylcholine on hypoglossal and C4 nerve activity in brainstem-spinal cord preparations from newborn rat. Respir Physiol Neurobiol. 2021 Nov;293:103737.
Fukushi I, Takeda K, Pokorski M, Kono Y, Yoshizawa M, Hasebe Y, Nakao A, Mori Y, Onimaru H, Okada Y. Activation of Astrocytes in the Persistence of Post-hypoxic Respiratory Augmentation. Front Physiol. 2021 Oct 8;12:757731.
Yoshida Y, Azuma M, Furukawa K, Mizuno K, Den H, Kamiya T, Izumizaki M. Microwave Heating of Human Milk With Direct Temperature Monitoring. J Hum Lact. 2021 Oct 27:8903344211047452.
Ota S, Sugawa S, Suematsu E, Shinoda M, Izumizaki M, Shinkai M. Possibility of underestimation of COVID-19 prevalence by PCR and serological tests. J Microbiol Immunol Infect. 2021 Sep 29:S1684-1182(21)00192-4.
Masaoka Y, Sugiyama H, Yoshida M, Yoshikawa A, Honma M, Koiwa N, Kamijo S, Watanabe K, Kubota S, Iizuka N, Ida M, Ono K, Izumizaki M. Odors Associated With Autobiographical Memory Induce Visual Imagination of Emotional Scenes as Well as Orbitofrontal-Fusiform Activation. Front Neurosci. 2021 Aug 3;15:709050.
Uchida Y, Izumizaki M. Effect of menstrual cycle and female hormones on TRP and TREK channels in modifying thermosensitivity and physiological functions in women. J Therm Biol. 2021 Aug;100:103029.
Wada S, Honma M, Masaoka Y, Yoshida M, Koiwa N, Sugiyama H, Iizuka N, Kubota S, Kokudai Y, Yoshikawa A, Kamijo S, Kamimura S, Ida M, Ono K, Onda H, Izumizaki M. Volume of the right supramarginal gyrus is associated with a maintenance of emotion recognition ability. PLoS One. 2021 Jul 22;16(7):e0254623.
Honma M, Murakami H, Yabe Y, Kuroda T, Futamura A, Sugimoto A, Terao Y, Masaoka Y, Izumizaki M, Kawamura M, Ono K. Stopwatch training improves cognitive functions in patients with Parkinson's disease. J Neurosci Res. 2021 May;99(5):1325-1336.
Iizuka N, Masaoka Y, Kubota S, Sugiyama H, Yoshida M, Yoshikawa A, Koiwa N, Honma M, Watanabe K, Kamijo S, Kamimura S, Ida M, Ono K, Izumizaki M. Entorhinal cortex and parahippocampus volume reductions impact olfactory decline in aged subjects. Brain Behav. 2021 May;11(5):e02115.
Uchida Y, Sato I, Atsumi K, Tsunekawa C. UCP1 and TRPM8 expression in the brown fat did not affect the restriction of menthol-induced hyperthermia by estradiol in ovariectomized rats. J Nutr Sci Vitaminol. 2021 May 67(2);130-134.
Onimaru H, Yazawa I, Takeda K, Fukushi I, Okada Y. Calcium Imaging Analysis of Cellular Responses to Hypercapnia and Hypoxia in the NTS of Newborn Rat Brainstem Preparation. Front Physiol. 2021 Mar 25;12:645904.
Terao Y, Honma M, Asahara Y, Tokushige SI, Furubayashi T, Miyazaki T, Inomata-Terada S, Uchibori A, Miyagawa S, Ichikawa Y, Chiba A, Ugawa Y, Suzuki M. Time Distortion in Parkinsonism. Front Neurosci. 2021 Mar 19;15:648814.
Matsuno S, Yoshiike T, Yoshimura A, Morita S, Fujii Y, Honma M, Ozeki Y, Kuriyama K. Contribution of Somatosensory and Parietal Association Areas in Improving Standing Postural Stability Through Standing Plantar Perception Training in Community-Dwelling Older Adults. J Aging Phys Act. 2021 Feb 10;29(5):761-770.
Onimaru H, Ikeda K. Optogenetic Approach to Local Neuron Network Analysis of the Medullary Respiratory Center. Adv Exp Med Biol. 2021;1293:449-458.
2020年業績
Kubota S, Masaoka Y, Sugiyama H, Yoshida M, Yoshikawa A, Koiwa N, Honma M, Kinno R, Watanabe K, Iizuka N, Ida M, Ono K, Izumizaki M. Hippocampus and Parahippocampus Volume Reduction Associated With Impaired Olfactory Abilities in Subjects Without Evidence of Cognitive Decline. Front Hum Neurosci. 2020 Sep 30;14:556519.
Masaoka Y, Velakoulis D, Brewer WJ, Cropley VL, Bartholomeusz CF, Yung AR, Nelson B, Dwyer D, Wannan CMJ, Izumizaki M, McGorry PD, Wood SJ, Pantelis C. Impaired olfactory ability associated with larger left hippocampus and rectus volumes at earliest stages of schizophrenia: A sign of neuroinflammation? Psychiatry Res. 2020 Jul;289:112909.
Yoshikawa A, Masaoka Y, Yoshida M, Koiwa N, Honma M, Watanabe K, Kubota S, Natsuko I, Ida M, Izumizaki M. Heart Rate and Respiration Affect the Functional Connectivity of Default Mode Network in Resting-State Functional Magnetic Resonance Imaging. Front Neurosci. 2020 Jun 30;14:631.
Kotani S, Yazawa I, Onimaru H, Izumizaki M. An aromatic substance, eugenol induces distinct depressant effects on respiratory activity in different postnatal developmental stages of the rat. Neurosci Res. 2020 Jun;155:20-26.
Yagura K, Ohtaki H, Tsumuraya T, Sato A, Miyamoto K, Kawada N, Suzuki K, Nakamura M, Kanzaki K, Dohi K, Izumizaki M, Hiraizumi Y, Honda K. The enhancement of CCL2 and CCL5 by human bone marrow-derived mesenchymal stem/stromal cells might contribute to inflammatory suppression and axonal extension after spinal cord injury. PLoS One. 2020 Mar 10;15(3):e0230080.
Morishita S, Hokamura K, Yoshikawa A, Agata N, Tsutsui Y, Umemura K, Kumada T. Different exercises can modulate the differentiation/maturation of neural stem/progenitor cells after photochemically induced focal cerebral infarction. Brain and Behavior. 2020 Mar;10(3):e01535.
Oshima N, Onimaru H, Yamagata A, Ito S, Imakiire T, Kumagai H. Rostral ventrolateral medulla neuron activity is suppressed by Klotho and stimulated by FGF23 in newborn Wistar rats. Auton Neurosci. 2020 Mar;224:102640.
Ohkuma R, Yada E, Ishikawa S, Komura D, Ishizaki H, Tamada K, Kubota Y, Hamada K, Ishida H, Hirasawa Y, Ariizumi H, Satoh E, Shida M, Watanabe M, Onoue R, Ando K, Tsurutani J, Yoshimura K, Yokobori T, Sasada T, Aoki T, Murakami M, Norose T, Ohike N, Takimoto M, Izumizaki M, Kobayashi S, Tsunoda T, Wada S. High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer. PLoS One. 2020 Jan 10;15(1):e0226707.
Kuroda T, Honma M, Mori Y, Futamura A, Sugimoto A, Yano S, Kinno R, Murakami H, Ono K. Increased Presence of Cerebral Microbleeds Correlates With Ventricular Enlargement and Increased White Matter Hyperintensities in Alzheimer's Disease. Front Aging Neurosci. 2020 Jan 31;12:13.
Masaoka Y, Velakoulis D, Brewer WJ, Cropley VL, Bartholomeusz CF, Yung AR, Nelson B, Dwyer D, Wannan CMJ, Izumizaki M, McGorry PD, Wood SJ, Pantelis C. Impaired olfactory ability associated with larger left hippocampus and rectus volumes at earliest stages of schizophrenia: A sign of neuroinflammation? Psychiatry Res. 2020 Jul;289:112909.
Yoshikawa A, Masaoka Y, Yoshida M, Koiwa N, Honma M, Watanabe K, Kubota S, Natsuko I, Ida M, Izumizaki M. Heart Rate and Respiration Affect the Functional Connectivity of Default Mode Network in Resting-State Functional Magnetic Resonance Imaging. Front Neurosci. 2020 Jun 30;14:631.
Kotani S, Yazawa I, Onimaru H, Izumizaki M. An aromatic substance, eugenol induces distinct depressant effects on respiratory activity in different postnatal developmental stages of the rat. Neurosci Res. 2020 Jun;155:20-26.
Yagura K, Ohtaki H, Tsumuraya T, Sato A, Miyamoto K, Kawada N, Suzuki K, Nakamura M, Kanzaki K, Dohi K, Izumizaki M, Hiraizumi Y, Honda K. The enhancement of CCL2 and CCL5 by human bone marrow-derived mesenchymal stem/stromal cells might contribute to inflammatory suppression and axonal extension after spinal cord injury. PLoS One. 2020 Mar 10;15(3):e0230080.
Morishita S, Hokamura K, Yoshikawa A, Agata N, Tsutsui Y, Umemura K, Kumada T. Different exercises can modulate the differentiation/maturation of neural stem/progenitor cells after photochemically induced focal cerebral infarction. Brain and Behavior. 2020 Mar;10(3):e01535.
Oshima N, Onimaru H, Yamagata A, Ito S, Imakiire T, Kumagai H. Rostral ventrolateral medulla neuron activity is suppressed by Klotho and stimulated by FGF23 in newborn Wistar rats. Auton Neurosci. 2020 Mar;224:102640.
Ohkuma R, Yada E, Ishikawa S, Komura D, Ishizaki H, Tamada K, Kubota Y, Hamada K, Ishida H, Hirasawa Y, Ariizumi H, Satoh E, Shida M, Watanabe M, Onoue R, Ando K, Tsurutani J, Yoshimura K, Yokobori T, Sasada T, Aoki T, Murakami M, Norose T, Ohike N, Takimoto M, Izumizaki M, Kobayashi S, Tsunoda T, Wada S. High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer. PLoS One. 2020 Jan 10;15(1):e0226707.
Kuroda T, Honma M, Mori Y, Futamura A, Sugimoto A, Yano S, Kinno R, Murakami H, Ono K. Increased Presence of Cerebral Microbleeds Correlates With Ventricular Enlargement and Increased White Matter Hyperintensities in Alzheimer's Disease. Front Aging Neurosci. 2020 Jan 31;12:13.
2019年業績
Ikeda K, Igarashi H, Yawo H, Kobayashi K, Arata S, Kawakami K, Izumizaki M, Onimaru H. Optogenetic analysis of respiratory neuronal networks in the ventral medulla of neonatal rats producing channelrhodopsin in Phox2b-positive cells. Pflugers Arch. 2019 Dec;471(11-12):1419-1439.
Yoshiike T, Honma M, Ikeda H, Kuriyama K. Bright light exposure advances consolidation of motor skill accuracy in humans. Neurobiol Learn Mem. 2019 Dec;166:107084.
Takahashi T, Nakamura M, Sasabayashi D, Nishikawa Y, Takayanagi Y, Furuichi A, Kido M, Mizukami Y, Nishiyama S, Higuchi Y, Tateno T, Itoh H, Noguchi K, Masaoka Y, Suzuki M. (2019) Association between olfactory sulcus morphology and olfactory functioning in schizophrenia and psychosis high-risk status. Heliyon, Oct 10; 5(10):e02642.
Ikeda K, Onimaru H, Matsuura T, Kawakami K. Different impacts on brain function depending on the mode of delivery. Brain Res. 2019 Oct 1720:146289.
Ikeda K, Onimaru H, Inada H, Tien Lin S, Arata S, Osumi N. Structural and functional defects of the respiratory neural system in the medulla and spinal cord of Pax6 mutant rats. Brain Res Bull. 2019 Oct;152:107-116.
Honma M, Itoi C, Midorikawa A, Terao Y, Masaoka Y, Kuroda T, Futamura A, Shiromaru A, Ohta H, Kato N, Kawamura M, Ono K. Contraction of distance and duration production in autism spectrum disorder. Sci Rep. 2019 Jun 19;9(1):8806.
Iigaya K, Minoura Y, Onimaru H, Kotani S, Izumizaki M. Effects of Feeding-Related Peptides on Neuronal Oscillation in the Ventromedial Hypothalamus. J Clin Med. 2019 Mar 1;8(3): E292.
Ikeda K, Kaneko R, Yanagawa Y, Ogawa M, Kobayashi K, Arata S, Kawakami K, Onimaru H. Analysis of the neuronal network of the medullary respiratory center in transgenic rats expressing archaerhodopsin-3 in Phox2b-expressing cells. Brain Res Bull. 2019 Jan;144:39-45.
Oka A, Iizuka M, Onimaru H, Izumizaki M. Inhibitory Thoracic Interneurons are not Essential to Generate the Rostro-caudal Gradient of the Thoracic Inspiratory Motor Activity in Neonatal Rat. Neuroscience. 2019 Jan 15;397:1-11.
Yoshiike T, Honma M, Ikeda H, Kuriyama K. Bright light exposure advances consolidation of motor skill accuracy in humans. Neurobiol Learn Mem. 2019 Dec;166:107084.
Takahashi T, Nakamura M, Sasabayashi D, Nishikawa Y, Takayanagi Y, Furuichi A, Kido M, Mizukami Y, Nishiyama S, Higuchi Y, Tateno T, Itoh H, Noguchi K, Masaoka Y, Suzuki M. (2019) Association between olfactory sulcus morphology and olfactory functioning in schizophrenia and psychosis high-risk status. Heliyon, Oct 10; 5(10):e02642.
Ikeda K, Onimaru H, Matsuura T, Kawakami K. Different impacts on brain function depending on the mode of delivery. Brain Res. 2019 Oct 1720:146289.
Ikeda K, Onimaru H, Inada H, Tien Lin S, Arata S, Osumi N. Structural and functional defects of the respiratory neural system in the medulla and spinal cord of Pax6 mutant rats. Brain Res Bull. 2019 Oct;152:107-116.
Honma M, Itoi C, Midorikawa A, Terao Y, Masaoka Y, Kuroda T, Futamura A, Shiromaru A, Ohta H, Kato N, Kawamura M, Ono K. Contraction of distance and duration production in autism spectrum disorder. Sci Rep. 2019 Jun 19;9(1):8806.
Iigaya K, Minoura Y, Onimaru H, Kotani S, Izumizaki M. Effects of Feeding-Related Peptides on Neuronal Oscillation in the Ventromedial Hypothalamus. J Clin Med. 2019 Mar 1;8(3): E292.
Ikeda K, Kaneko R, Yanagawa Y, Ogawa M, Kobayashi K, Arata S, Kawakami K, Onimaru H. Analysis of the neuronal network of the medullary respiratory center in transgenic rats expressing archaerhodopsin-3 in Phox2b-expressing cells. Brain Res Bull. 2019 Jan;144:39-45.
Oka A, Iizuka M, Onimaru H, Izumizaki M. Inhibitory Thoracic Interneurons are not Essential to Generate the Rostro-caudal Gradient of the Thoracic Inspiratory Motor Activity in Neonatal Rat. Neuroscience. 2019 Jan 15;397:1-11.
2018年業績
Iizuka M, Ikeda K, Onimaru H, Izumizaki M. Expressions of VGLUT1/2 in the inspiratory interneurons and GAD65/67 in the inspiratory Renshaw cells in the neonatal rat upper thoracic spinal cord. IBRO Rep. 2018 Aug 4;5:24-32.
Watanabe K, Masaoka Y, Kawamura M, Yoshida M, Koiwa N, Yoshikawa A, Kubota S, Ida M, Ono K, Izumizaki M. Left Posterior Orbitofrontal Cortex Is Associated With Odor-Induced Autobiographical Memory: An fMRI Study. Front Psychol. 2018 May 11;9:687.
Yagura S, Onimaru H, Kanzaki K, Izumizaki M. Inhibitory effects of eugenol on putative nociceptive response in spinal cord preparation isolated from neonatal rats. Exp Brain Res. 2018 Jun;236(6):1767-1774.
Iizuka M, Kobayashi M, Hasegawa Y, Tomita K, Takeshima R, Izumizaki M. A new flexible piezoelectric pressure sensor array for the noninvasive detection of laryngeal movement during swallowing. J Physiol Sci. 2018 Nov;68(6):837-846.
Honma M, Masaoka Y, Kuroda T, Futamura A, Shiromaru A, Izumizaki M, Kawamura M. Impairment of cross-modality of vision and olfaction in Parkinson disease. Neurology. 2018 Mar 13;90(11):e977-e984.
Kotani S, Irie S, Izumizaki M, Onimaru H. Effects of eugenol on respiratory burst generation in newborn rat brainstem-spinal cord preparations. Pflugers Arch. 2018 Feb;470(2):385-394.
Bautista TG, Fong AY, Pilowsky PM, Ikeda K, Kawakami K, Spirovski D, Onimaru H. The Expression of Galanin in the Parafacial Respiratory Group and its Effects on Respiration in Neonatal Rats. Neuroscience. 2018 Aug 1;384:1-13.
Minoura Y, Onimaru H, Iigaya K, Kobayashi Y. Modulation of sympathetic preganglionic neuron activity via adrenergic receptors. Hypertens Res. 2018 Jul;41(7):499-505.
Igarashi H, Ikeda K, Onimaru H, Kaneko R, Koizumi K, Beppu K, Nishizawa K, Takahashi Y, Kato F, Matsui K, Kobayashi K, Yanagawa Y, Muramatsu SI, Ishizuka T, Yawo H. Targeted expression of step-function opsins in transgenic rats for optogenetic studies. Sci Rep. 2018 Apr 3;8(1):5435.
Oshima N, Onimaru H, Yamagata A, Itoh S, Matsubara H, Imakiire T, Nishida Y, Kumagai H. Erythropoietin, a putative neurotransmitter during hypoxia, is produced in RVLM neurons and activates them in neonatal Wistar rats. Am J Physiol Regul Integr Comp Physiol. 2018 May 1;314(5):R700-R708.
Onimaru H, Nakamura S, Ikeda K, Kawakami K, Inoue T. Confocal calcium imaging analysis of respiratory-related burst activity in the parafacial region. Brain Res Bull. 2018 May;139:16-20.
Honma M, Masaoka Y, Koyama S, Kuroda T, Futamura A, Shiromaru A, Terao Y, Ono K, Kawamura M. Impaired cognitive modification for estimating time duration in Parkinson's disease. PLoS One. 2018 Dec 13;13(12):e0208956.
Takahashi T, Nakamura M, Sasabayashi D, Komori Y, Higuchi Y, Nishikawa Y, Nishiyama S, Itoh H, Masaoka Y, Suzuki M. Olfactory deficits in individuals at risk for psychosis and patients with schizophrenia: relationship with socio-cognitive functions and symptom severity. Eur Arch Psychiatry Clin Neurosci. 2018 Oct;268(7):689-698.
Watanabe K, Masaoka Y, Kawamura M, Yoshida M, Koiwa N, Yoshikawa A, Kubota S, Ida M, Ono K, Izumizaki M. Left Posterior Orbitofrontal Cortex Is Associated With Odor-Induced Autobiographical Memory: An fMRI Study. Front Psychol. 2018 May 11;9:687.
Yagura S, Onimaru H, Kanzaki K, Izumizaki M. Inhibitory effects of eugenol on putative nociceptive response in spinal cord preparation isolated from neonatal rats. Exp Brain Res. 2018 Jun;236(6):1767-1774.
Iizuka M, Kobayashi M, Hasegawa Y, Tomita K, Takeshima R, Izumizaki M. A new flexible piezoelectric pressure sensor array for the noninvasive detection of laryngeal movement during swallowing. J Physiol Sci. 2018 Nov;68(6):837-846.
Honma M, Masaoka Y, Kuroda T, Futamura A, Shiromaru A, Izumizaki M, Kawamura M. Impairment of cross-modality of vision and olfaction in Parkinson disease. Neurology. 2018 Mar 13;90(11):e977-e984.
Kotani S, Irie S, Izumizaki M, Onimaru H. Effects of eugenol on respiratory burst generation in newborn rat brainstem-spinal cord preparations. Pflugers Arch. 2018 Feb;470(2):385-394.
Bautista TG, Fong AY, Pilowsky PM, Ikeda K, Kawakami K, Spirovski D, Onimaru H. The Expression of Galanin in the Parafacial Respiratory Group and its Effects on Respiration in Neonatal Rats. Neuroscience. 2018 Aug 1;384:1-13.
Minoura Y, Onimaru H, Iigaya K, Kobayashi Y. Modulation of sympathetic preganglionic neuron activity via adrenergic receptors. Hypertens Res. 2018 Jul;41(7):499-505.
Igarashi H, Ikeda K, Onimaru H, Kaneko R, Koizumi K, Beppu K, Nishizawa K, Takahashi Y, Kato F, Matsui K, Kobayashi K, Yanagawa Y, Muramatsu SI, Ishizuka T, Yawo H. Targeted expression of step-function opsins in transgenic rats for optogenetic studies. Sci Rep. 2018 Apr 3;8(1):5435.
Oshima N, Onimaru H, Yamagata A, Itoh S, Matsubara H, Imakiire T, Nishida Y, Kumagai H. Erythropoietin, a putative neurotransmitter during hypoxia, is produced in RVLM neurons and activates them in neonatal Wistar rats. Am J Physiol Regul Integr Comp Physiol. 2018 May 1;314(5):R700-R708.
Onimaru H, Nakamura S, Ikeda K, Kawakami K, Inoue T. Confocal calcium imaging analysis of respiratory-related burst activity in the parafacial region. Brain Res Bull. 2018 May;139:16-20.
Honma M, Masaoka Y, Koyama S, Kuroda T, Futamura A, Shiromaru A, Terao Y, Ono K, Kawamura M. Impaired cognitive modification for estimating time duration in Parkinson's disease. PLoS One. 2018 Dec 13;13(12):e0208956.
Takahashi T, Nakamura M, Sasabayashi D, Komori Y, Higuchi Y, Nishikawa Y, Nishiyama S, Itoh H, Masaoka Y, Suzuki M. Olfactory deficits in individuals at risk for psychosis and patients with schizophrenia: relationship with socio-cognitive functions and symptom severity. Eur Arch Psychiatry Clin Neurosci. 2018 Oct;268(7):689-698.
2017年業績
Murai N, Ohtaki H, Watanabe J, Xu Z, Sasaki S, Yagura K, Shioda S, Nagasaka S, Honda K, Izumizaki M. Intrapancreatic injection of human bone marrow-derived mesenchymal stem/stromal cells alleviates hyperglycemia and modulates the macrophage state in streptozotocin-induced type 1 diabetic mice. PLoS One. 2017 Oct 26;12(10):e0186637.
Tsukada S, Masaoka Y, Yoshikawa A, Okamoto K, Homma I, Izumizaki M. Coupling of dyspnea perception and occurrence of tachypnea during exercise. J Physiol Sci. 2017 Jan;67(1):173-180.
Iigaya K, Okazaki S, Minoura Y, Onimaru H. Interaction between novel oscillation within the ventromedial hypothalamus and the sympathetic nervous system. Neuroscience. 2017 Feb 20;343:213-221.
Ikeda K, Kawakami K, Onimaru H, Okada Y, Yokota S, Koshiya N, Oku Y, Iizuka M, Koizumi H. The respiratory control mechanisms in the brainstem and spinal cord: integrative views of the neuroanatomy and neurophysiology. J Physiol Sci. 2017 Jan;67(1):45-62.
Ikeda K, Onimaru H, Kawakami K. Knockout of sodium pump α3 subunit gene (Atp1a3(-/-)) results in perinatal seizure and defective respiratory rhythm generation. Brain Res. 2017 Jul 1;1666:27-37.
Lin ST, Ohbayashi M, Yamamoto T, Onimaru H, Kogo M. Effects of riluzole on spinal seizure-like activity in the brainstem-spinal cord preparation of newborn rat. Neurosci Res. 2017 Dec;125:46-53.
Masaoka H, Ito H, Gallus S, Watanabe M, Yokomizo A, Eto M, Matsuo K. Combination of ALDH2 and ADH1B polymorphisms is associated with smoking initiation: A large-scale cross-sectional study in a Japanese population. Drug Alcohol Depend. 2017 Apr 1;173:85-91.
Murai N, Saiki R, Hashizume M, Kigawa Y, Koizumi G, Tadokoro R, Endo K, Iizaka T, Otsuka F, Izumizaki M, Nagasaka S. Alcohol flushing is independently associated with lesser degree of carotid atherosclerosis in Japanese type 2 diabetic patients. Diabetol Int. 2017 Jul 28;9(1):68-74.
Nagoya K, Nakamura S, Ikeda K, Onimaru H, Yoshida A, Nakayama K, Mochizuki A, Kiyomoto M, Sato F, Kawakami K, Takahashi K, Inoue T. Distinctive features of Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus. Neuroscience. 2017 Sep 1;358:211-226.
Oshima N, Onimaru H, Matsubara H, Uchida T, Watanabe A, Imakiire T, Nishida Y, Kumagai H. Direct effects of glucose, insulin, GLP-1, and GIP on bulbospinal neurons in the rostral ventrolateral medulla in neonatal wistar rats. Neuroscience. 2017 Mar 6;344:74-88.
Oyama Y, Iigaya K, Minoura Y, Okabe T, Izumizaki M, Onimaru H. An in vitro experimental model for analysis of central control of sympathetic nerve activity. J Physiol Sci. 2017 Sep;67(5):629-635.
Tani M, Kotani S, Hayakawa C, Lin ST, Irie S, Ikeda K, Kawakami K, Onimaru H. Effects of a TRPV1 agonist capsaicin on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats. Pflugers Arch. 2017 Feb;469(2):327-338.
Tsukada S, Masaoka Y, Yoshikawa A, Okamoto K, Homma I, Izumizaki M. Coupling of dyspnea perception and occurrence of tachypnea during exercise. J Physiol Sci. 2017 Jan;67(1):173-180.
Iigaya K, Okazaki S, Minoura Y, Onimaru H. Interaction between novel oscillation within the ventromedial hypothalamus and the sympathetic nervous system. Neuroscience. 2017 Feb 20;343:213-221.
Ikeda K, Kawakami K, Onimaru H, Okada Y, Yokota S, Koshiya N, Oku Y, Iizuka M, Koizumi H. The respiratory control mechanisms in the brainstem and spinal cord: integrative views of the neuroanatomy and neurophysiology. J Physiol Sci. 2017 Jan;67(1):45-62.
Ikeda K, Onimaru H, Kawakami K. Knockout of sodium pump α3 subunit gene (Atp1a3(-/-)) results in perinatal seizure and defective respiratory rhythm generation. Brain Res. 2017 Jul 1;1666:27-37.
Lin ST, Ohbayashi M, Yamamoto T, Onimaru H, Kogo M. Effects of riluzole on spinal seizure-like activity in the brainstem-spinal cord preparation of newborn rat. Neurosci Res. 2017 Dec;125:46-53.
Masaoka H, Ito H, Gallus S, Watanabe M, Yokomizo A, Eto M, Matsuo K. Combination of ALDH2 and ADH1B polymorphisms is associated with smoking initiation: A large-scale cross-sectional study in a Japanese population. Drug Alcohol Depend. 2017 Apr 1;173:85-91.
Murai N, Saiki R, Hashizume M, Kigawa Y, Koizumi G, Tadokoro R, Endo K, Iizaka T, Otsuka F, Izumizaki M, Nagasaka S. Alcohol flushing is independently associated with lesser degree of carotid atherosclerosis in Japanese type 2 diabetic patients. Diabetol Int. 2017 Jul 28;9(1):68-74.
Nagoya K, Nakamura S, Ikeda K, Onimaru H, Yoshida A, Nakayama K, Mochizuki A, Kiyomoto M, Sato F, Kawakami K, Takahashi K, Inoue T. Distinctive features of Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus. Neuroscience. 2017 Sep 1;358:211-226.
Oshima N, Onimaru H, Matsubara H, Uchida T, Watanabe A, Imakiire T, Nishida Y, Kumagai H. Direct effects of glucose, insulin, GLP-1, and GIP on bulbospinal neurons in the rostral ventrolateral medulla in neonatal wistar rats. Neuroscience. 2017 Mar 6;344:74-88.
Oyama Y, Iigaya K, Minoura Y, Okabe T, Izumizaki M, Onimaru H. An in vitro experimental model for analysis of central control of sympathetic nerve activity. J Physiol Sci. 2017 Sep;67(5):629-635.
Tani M, Kotani S, Hayakawa C, Lin ST, Irie S, Ikeda K, Kawakami K, Onimaru H. Effects of a TRPV1 agonist capsaicin on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats. Pflugers Arch. 2017 Feb;469(2):327-338.
2016年業績
Iizuka M, Onimaru H, Izumizaki M. Distribution of respiration-related neuronal activity in the thoracic spinal cord of the neonatal rat: An optical imaging study. Neuroscience. 2016 Feb 19;315:217-27.
Igarashi H, Koizumi K, Kaneko R, Ikeda K, Egawa R, Yanagawa Y, Muramatsu S, Onimaru H, Ishizuka T, Yawo H. A Novel Reporter Rat Strain That Conditionally Expresses the Bright Red Fluorescent Protein tdTomato. PLoS One. 2016 May 19;11(5):e0155687.
Shakuo T, Lin ST, Onimaru H. The Effects of Lidocaine on Central Respiratory Neuron Activity and Nociceptive-Related Responses in the Brainstem-Spinal Cord Preparation of the Newborn Rat. Anesth Analg. 2016 May;122(5):1586-93.
Takahashi K, Hayakawa C, Onimaru H. Effects of a quaternary lidocaine derivative, QX-314, on the respiratory activity in brainstem-spinal cord preparation from newborn rats. Neurosci Lett. 2016 Apr 21;619:121-5.
Masaoka Y, Zalesky A., Tatsuno M, Okamoto S, Yoshida M., Koiwa N, Kobayakawa M, Watanabe K, Ida M, Homma I, Izumizaki M, Pantelis C. Inter- and intra-hemispheric fibers of olfactory and motor areas in Kallmann syndrome with defective corpus callosum. Journal of Neurology & Neurophysiology, 2016 7:3
Masaoka Y, Phillips A. Does the occurrence of sleep disorder or deficits in olfaction provide an early indication of neurodegeneration and subsequent dementia? Journal of Alzheimer’s Disease& Parkinsonism, 2016 6: 3
Igarashi H, Koizumi K, Kaneko R, Ikeda K, Egawa R, Yanagawa Y, Muramatsu S, Onimaru H, Ishizuka T, Yawo H. A Novel Reporter Rat Strain That Conditionally Expresses the Bright Red Fluorescent Protein tdTomato. PLoS One. 2016 May 19;11(5):e0155687.
Shakuo T, Lin ST, Onimaru H. The Effects of Lidocaine on Central Respiratory Neuron Activity and Nociceptive-Related Responses in the Brainstem-Spinal Cord Preparation of the Newborn Rat. Anesth Analg. 2016 May;122(5):1586-93.
Takahashi K, Hayakawa C, Onimaru H. Effects of a quaternary lidocaine derivative, QX-314, on the respiratory activity in brainstem-spinal cord preparation from newborn rats. Neurosci Lett. 2016 Apr 21;619:121-5.
Masaoka Y, Zalesky A., Tatsuno M, Okamoto S, Yoshida M., Koiwa N, Kobayakawa M, Watanabe K, Ida M, Homma I, Izumizaki M, Pantelis C. Inter- and intra-hemispheric fibers of olfactory and motor areas in Kallmann syndrome with defective corpus callosum. Journal of Neurology & Neurophysiology, 2016 7:3
Masaoka Y, Phillips A. Does the occurrence of sleep disorder or deficits in olfaction provide an early indication of neurodegeneration and subsequent dementia? Journal of Alzheimer’s Disease& Parkinsonism, 2016 6: 3
2015年業績
Kigawa K, Izumizaki M, Tsukada S, Hakuta N. Proprioceptive Interaction between the Two Arms in a Single-Arm Pointing Task. PLoS One. 2015 Aug 28;10(8):e0137031.
Takayama M, Yajima H, Kawase A, Homma I, Izumizaki M, Takakura N. Is Skin-Touch Sham Needle Not Placebo? A Double-Blind Crossover Study on Pain Alleviation. Evid Based Complement Alternat Med. 2015;2015:152086.
Izumizaki M. Breathing is affected by dopamine D2-like receptors in the basolateral amygdala. Respir Physiol Neurobiol. 2015 Apr;209:23-7.
Oshima N, Onimaru H, Matsubara H, Uchida T, Watanabe A, Takechi H, Nishida Y, Kumagai H. Uric acid, indoxyl sulfate, and methylguanidine activate bulbospinal neurons in the RVLM via their specific transporters and by producing oxidative stress. Neuroscience. 2015 Sep 24;304:133-45.
Ikeda K, Takahashi M, Sato S, Igarashi H, Ishizuka T, Yawo H, Arata S, Southard-Smith EM, Kawakami K, Onimaru H. A Phox2b BAC Transgenic Rat Line Useful for Understanding Respiratory Rhythm Generator Neural Circuitry. PLoS One.2015 Jul 6;10(7):e0132475.
Tani M, Yazawa I, Ikeda K, Kawakami K, Onimaru H. Long-lasting facilitation of respiratory rhythm by treatment with TRPA1 agonist, cinnamaldehyde. J Neurophysiol. 2015 Aug;114(2):989-98.
Tsuzawa K, Minoura Y, Takeda S, Inagaki K, Onimaru H. Effects of α2-adorenoceptor agonist dexmedetomidine on respiratory rhythm generation of newborn rats. Neurosci Lett. 2015 Jun 15;597:117-20.
Onimaru H, Tsuzawa K, Nakazono Y, Janczewski WA. Midline section of the medulla abolishes inspiratory activity and desynchronizes pre-inspiratory neuron rhythm on both sides of the medulla in newborn rats. J Neurophysiol. 2015 Apr 1;113(7):2871-8.
Tsuzawa K, Yazawa I, Shakuo T, Ikeda K, Kawakami K, Onimaru H. Effects of ouabain on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats and in decerebrate and arterially perfused in situ preparation from juvenile rats. Neuroscience. 2015 Feb 12;286:404-11.
Lin ST, Onimaru H. Effects of riluzole on respiratory rhythm generation in the brainstem-spinal cord preparation from newborn rat. Neurosci Res. 2015 May;94:28-36.
Takahashi T, Itoh H, Nishikawa Y, Higuchi Y, Nakamura M, Sasabayashi D, Nishiyama S, Mizukami Y, Masaoka Y, Suzuki M. Possible relation between olfaction and anxiety in healthy subjects. Psychiatry Clin Neurosci. 2015 Jul;69(7):431-8.
Takayama M, Yajima H, Kawase A, Homma I, Izumizaki M, Takakura N. Is Skin-Touch Sham Needle Not Placebo? A Double-Blind Crossover Study on Pain Alleviation. Evid Based Complement Alternat Med. 2015;2015:152086.
Izumizaki M. Breathing is affected by dopamine D2-like receptors in the basolateral amygdala. Respir Physiol Neurobiol. 2015 Apr;209:23-7.
Oshima N, Onimaru H, Matsubara H, Uchida T, Watanabe A, Takechi H, Nishida Y, Kumagai H. Uric acid, indoxyl sulfate, and methylguanidine activate bulbospinal neurons in the RVLM via their specific transporters and by producing oxidative stress. Neuroscience. 2015 Sep 24;304:133-45.
Ikeda K, Takahashi M, Sato S, Igarashi H, Ishizuka T, Yawo H, Arata S, Southard-Smith EM, Kawakami K, Onimaru H. A Phox2b BAC Transgenic Rat Line Useful for Understanding Respiratory Rhythm Generator Neural Circuitry. PLoS One.2015 Jul 6;10(7):e0132475.
Tani M, Yazawa I, Ikeda K, Kawakami K, Onimaru H. Long-lasting facilitation of respiratory rhythm by treatment with TRPA1 agonist, cinnamaldehyde. J Neurophysiol. 2015 Aug;114(2):989-98.
Tsuzawa K, Minoura Y, Takeda S, Inagaki K, Onimaru H. Effects of α2-adorenoceptor agonist dexmedetomidine on respiratory rhythm generation of newborn rats. Neurosci Lett. 2015 Jun 15;597:117-20.
Onimaru H, Tsuzawa K, Nakazono Y, Janczewski WA. Midline section of the medulla abolishes inspiratory activity and desynchronizes pre-inspiratory neuron rhythm on both sides of the medulla in newborn rats. J Neurophysiol. 2015 Apr 1;113(7):2871-8.
Tsuzawa K, Yazawa I, Shakuo T, Ikeda K, Kawakami K, Onimaru H. Effects of ouabain on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats and in decerebrate and arterially perfused in situ preparation from juvenile rats. Neuroscience. 2015 Feb 12;286:404-11.
Lin ST, Onimaru H. Effects of riluzole on respiratory rhythm generation in the brainstem-spinal cord preparation from newborn rat. Neurosci Res. 2015 May;94:28-36.
Takahashi T, Itoh H, Nishikawa Y, Higuchi Y, Nakamura M, Sasabayashi D, Nishiyama S, Mizukami Y, Masaoka Y, Suzuki M. Possible relation between olfaction and anxiety in healthy subjects. Psychiatry Clin Neurosci. 2015 Jul;69(7):431-8.
2014年業績
Sugita T, Kanamaru M, Iizuka M, Sato K, Tsukada S, Kawamura M, Homma I, Izumizaki M. Breathing is affected by dopamine D2-like receptors in the basolateral amygdala. Respir Physiol Neurobiol. 2015 Apr;209:23-7.
Takayama M, Yajima H, Kawase A, Homma I, Izumizaki M, Takakura N. The Potential of Double Blinding with Two Placebo Acupuncture Needles: A Randomize Controlled Pilot-Trial. Medicines (Basel). 2014 Dec 30;2(1):11-27.
Masaoka Y, Harding IH, Koiwa N, Yoshida M, Harrison BJ, Lorenzetti V, Ida M, Izumizaki M, Pantelis C, Homma I. The neural cascade of olfactory processing: a combined fMRI-EEG study. Respir Physiol Neurobiol. 2014 Dec 1;204:71-7.
Masaoka Y, Izumizaki M, Homma I. Where is the rhythm generator for emotional breathing? Prog Brain Res. 2014;209:367-77.
Hakuta N, Izumizaki M, Kigawa K, Murai N, Atsumi T, Homma I. Proprioceptive illusions created by vibration of one arm are altered by vibrating the other arm. Exp Brain Res. 2014 Jul;232(7):2197-206.
Onimaru H, Ikeda K, Mariho T, Kawakami K. Cytoarchitecture and CO(2) sensitivity of Phox2b-positive Parafacial neurons in the newborn rat medulla. Prog Brain Res. 2014;209:57-71.
Oshima N, Onimaru H, Yamamoto K, Takechi H, Nishida Y, Oda T, Kumagai H. Expression and functions of β1- and β2-adrenergic receptors on the bulbospinal neurons in the rostral ventrolateral medulla. Hypertens Res. 2014 Nov;37(11):976-83.
Takayama M, Yajima H, Kawase A, Homma I, Izumizaki M, Takakura N. The Potential of Double Blinding with Two Placebo Acupuncture Needles: A Randomize Controlled Pilot-Trial. Medicines (Basel). 2014 Dec 30;2(1):11-27.
Masaoka Y, Harding IH, Koiwa N, Yoshida M, Harrison BJ, Lorenzetti V, Ida M, Izumizaki M, Pantelis C, Homma I. The neural cascade of olfactory processing: a combined fMRI-EEG study. Respir Physiol Neurobiol. 2014 Dec 1;204:71-7.
Masaoka Y, Izumizaki M, Homma I. Where is the rhythm generator for emotional breathing? Prog Brain Res. 2014;209:367-77.
Hakuta N, Izumizaki M, Kigawa K, Murai N, Atsumi T, Homma I. Proprioceptive illusions created by vibration of one arm are altered by vibrating the other arm. Exp Brain Res. 2014 Jul;232(7):2197-206.
Onimaru H, Ikeda K, Mariho T, Kawakami K. Cytoarchitecture and CO(2) sensitivity of Phox2b-positive Parafacial neurons in the newborn rat medulla. Prog Brain Res. 2014;209:57-71.
Oshima N, Onimaru H, Yamamoto K, Takechi H, Nishida Y, Oda T, Kumagai H. Expression and functions of β1- and β2-adrenergic receptors on the bulbospinal neurons in the rostral ventrolateral medulla. Hypertens Res. 2014 Nov;37(11):976-83.
2013年業績
Yajima H, Takayama M, Kawase A, Takakura N, Izumizaki M, Homma I. Inhibitory Effect of Acupuncture on Vibration-Induced Finger Flexion Reflex in Humans: Comparisons Among Radial, Median, and Ulnar Nerve Stimulation. Med Acupunct. 2013 Aug;25(4):269-274.
Ohashi S, Izumizaki M, Atsumi T, Homma I. CO2 homeostasis is maintained in conscious humans by regulation of tidal volume, but not of respiratory rhythm. Respir Physiol Neurobiol. 2013 Apr 1;186(2):155-63.
Iwase M, Izumizaki M, Tsuchiya N, Homma I. Dopamine D1 receptors control exercise hyperpnoea in mice. Exp Physiol. 2013 Feb;98(2):491-500.
Izumizaki M, Iwase M, Tsuchiya N, Homma I. Hyperpnoeic response independent of limb movements at exercise onset in mice. Respir Physiol Neurobiol. 2013 Jan 15;185(2):319-31.
Masaoka Y, Pantelis C, Phillips A, Kawamura M, Mimura M, Minegishi G, Homma I. Markers of brain illness may be hidden in your olfactory ability: a Japanese perspective. Neurosci Lett. 2013 Aug 9;549:182-5.
Masaoka Y, Takayama M, Yajima H, Kawase A, Takakura N, Homma I. Analgesia Is Enhanced by Providing Information regarding Good Outcomes Associated with an Odor: Placebo Effects in Aromatherapy? Evid Based Complement Alternat Med. 2013;2013:921802.
Ohashi S, Izumizaki M, Atsumi T, Homma I. CO2 homeostasis is maintained in conscious humans by regulation of tidal volume, but not of respiratory rhythm. Respir Physiol Neurobiol. 2013 Apr 1;186(2):155-63.
Iwase M, Izumizaki M, Tsuchiya N, Homma I. Dopamine D1 receptors control exercise hyperpnoea in mice. Exp Physiol. 2013 Feb;98(2):491-500.
Izumizaki M, Iwase M, Tsuchiya N, Homma I. Hyperpnoeic response independent of limb movements at exercise onset in mice. Respir Physiol Neurobiol. 2013 Jan 15;185(2):319-31.
Masaoka Y, Pantelis C, Phillips A, Kawamura M, Mimura M, Minegishi G, Homma I. Markers of brain illness may be hidden in your olfactory ability: a Japanese perspective. Neurosci Lett. 2013 Aug 9;549:182-5.
Masaoka Y, Takayama M, Yajima H, Kawase A, Takakura N, Homma I. Analgesia Is Enhanced by Providing Information regarding Good Outcomes Associated with an Odor: Placebo Effects in Aromatherapy? Evid Based Complement Alternat Med. 2013;2013:921802.
2012年業績
Tsuge M, Izumizaki M, Kigawa K, Atsumi T, Homma I. Interaction between vibration-evoked proprioceptive illusions and mirror-evoked visual illusions in an arm-matching task. Exp Brain Res. 2012 Dec;223(4):541-51.
Tsuchiya N, Iwase M, Izumizaki M, Homma I. Dopaminergic modulation of exercise hyperpnoea via D(2) receptors in mice. Exp Physiol. 2012 Feb;97(2):228-38.
Tanabe A, Onimaru H, Suzuki H, Takeyama Y, Homma I. Effects of corticotropin-releasing factor on intermediolateral cell column neurons of newborn rats. Auton Neurosci. 2012 Nov 2;171(1-2):36-40.
Arata S, Nakamachi T, Onimaru H, Hashimoto H, Shioda S. Impaired response to hypoxia in the respiratory center is a major cause of neonatal death of the PACAP-knockout mouse. Eur J Neurosci. 2013 Feb;37(3):407-16.
Onimaru H, Ikeda K, Kawakami K. Relationship between the distribution of the paired-like homeobox gene (Phox2b) expressing cells and blood vessels in the parafacial region of the ventral medulla of neonatal rats. Neuroscience. 2012 Jun 14;212:131-9.
Onimaru H, Ikeda K, Kawakami K. Postsynaptic mechanisms of CO(2) responses in parafacial respiratory neurons of newborn rats. J Physiol. 2012 Apr 1;590(7):1615-24.
Onimaru H, Dutschmann M. Calcium imaging of neuronal activity in the most rostral
parafacial respiratory group of the newborn rat. J Physiol Sci. 2012 Jan;62(1):71-7.
Masaoka Y, Sugiyama H, Katayama A, Kashiwagi M, Homma I. Remembering the past with slow breathing associated with activity in the parahippocampus and amygdala. Neurosci Lett. 2012 Jul 19;521(2):98-103.
Masaoka Y, Sugiyama H, Katayama A, Kashiwagi M, Homma I. Slow breathing and emotions associated with odor-induced autobiographical memories. Chem Senses. 2012 May;37(4):379-88.
Kuroda T, Masaoka Y, Kasai H, Noguchi K, Kawamura M, Homma I. Sharing breathlessness: investigating respiratory change during observation of breath-holding in another. Respir Physiol Neurobiol. 2012 Mar 15;180(2-3):218-22.
Koyama S, Kobayakawa M, Tachibana N, Masaoka Y, Homma I, Ishii K, Kawamura M. Neuropsychological and radiological assessments of two cases with apparent idiopathic rapid eye movement sleep behaviour disorder. Eur Neurol. 2012;67(1):18-25.
Tsuchiya N, Iwase M, Izumizaki M, Homma I. Dopaminergic modulation of exercise hyperpnoea via D(2) receptors in mice. Exp Physiol. 2012 Feb;97(2):228-38.
Tanabe A, Onimaru H, Suzuki H, Takeyama Y, Homma I. Effects of corticotropin-releasing factor on intermediolateral cell column neurons of newborn rats. Auton Neurosci. 2012 Nov 2;171(1-2):36-40.
Arata S, Nakamachi T, Onimaru H, Hashimoto H, Shioda S. Impaired response to hypoxia in the respiratory center is a major cause of neonatal death of the PACAP-knockout mouse. Eur J Neurosci. 2013 Feb;37(3):407-16.
Onimaru H, Ikeda K, Kawakami K. Relationship between the distribution of the paired-like homeobox gene (Phox2b) expressing cells and blood vessels in the parafacial region of the ventral medulla of neonatal rats. Neuroscience. 2012 Jun 14;212:131-9.
Onimaru H, Ikeda K, Kawakami K. Postsynaptic mechanisms of CO(2) responses in parafacial respiratory neurons of newborn rats. J Physiol. 2012 Apr 1;590(7):1615-24.
Onimaru H, Dutschmann M. Calcium imaging of neuronal activity in the most rostral
parafacial respiratory group of the newborn rat. J Physiol Sci. 2012 Jan;62(1):71-7.
Masaoka Y, Sugiyama H, Katayama A, Kashiwagi M, Homma I. Remembering the past with slow breathing associated with activity in the parahippocampus and amygdala. Neurosci Lett. 2012 Jul 19;521(2):98-103.
Masaoka Y, Sugiyama H, Katayama A, Kashiwagi M, Homma I. Slow breathing and emotions associated with odor-induced autobiographical memories. Chem Senses. 2012 May;37(4):379-88.
Kuroda T, Masaoka Y, Kasai H, Noguchi K, Kawamura M, Homma I. Sharing breathlessness: investigating respiratory change during observation of breath-holding in another. Respir Physiol Neurobiol. 2012 Mar 15;180(2-3):218-22.
Koyama S, Kobayakawa M, Tachibana N, Masaoka Y, Homma I, Ishii K, Kawamura M. Neuropsychological and radiological assessments of two cases with apparent idiopathic rapid eye movement sleep behaviour disorder. Eur Neurol. 2012;67(1):18-25.
2011年業績
Izumizaki M, Masaoka Y, Homma I. Coupling of dyspnea perception and tachypneic breathing during hypercapnia. Respir Physiol Neurobiol. 2011 Dec 15;179(2-3):276-86.
Ohshima Y, Iwase M, Izumizaki M, Nakayama H, Narita I, Homma I. Effects of fasting on hypoxic ventilatory responses and the contribution of histamine H1 receptors in mice. J Physiol Sci. 2011 Mar;61(2):73-82.
Fujii T, Onimaru H, Homma I. Effects of corticotropin releasing factor on spontaneous burst activity in the piriform-amygdala complex of in vitro brain preparations from newborn rats. Neurosci Res. 2011 Oct;71(2):134-9.
Kashiwagi M, Osaka Y, Onimaru H, Takeda J. Optical imaging of propofol-induced central respiratory depression in medulla-spinal cord preparations from newborn rats. Clin Exp Pharmacol Physiol. 2011 Mar;38(3):186-91.
Masaoka Y, Kawamura M, Takeda A, Kobayakawa M, Kuroda T, Kasai H, Tsuruya N, Futamura A, Homma I. Impairment of odor recognition and odor-induced emotions in type 1 myotonic dystrophy. Neurosci Lett. 2011 Oct 10;503(3):163-6.
Ohshima Y, Iwase M, Izumizaki M, Nakayama H, Narita I, Homma I. Effects of fasting on hypoxic ventilatory responses and the contribution of histamine H1 receptors in mice. J Physiol Sci. 2011 Mar;61(2):73-82.
Fujii T, Onimaru H, Homma I. Effects of corticotropin releasing factor on spontaneous burst activity in the piriform-amygdala complex of in vitro brain preparations from newborn rats. Neurosci Res. 2011 Oct;71(2):134-9.
Kashiwagi M, Osaka Y, Onimaru H, Takeda J. Optical imaging of propofol-induced central respiratory depression in medulla-spinal cord preparations from newborn rats. Clin Exp Pharmacol Physiol. 2011 Mar;38(3):186-91.
Masaoka Y, Kawamura M, Takeda A, Kobayakawa M, Kuroda T, Kasai H, Tsuruya N, Futamura A, Homma I. Impairment of odor recognition and odor-induced emotions in type 1 myotonic dystrophy. Neurosci Lett. 2011 Oct 10;503(3):163-6.
2010年業績
Iwase M, Ohshima Y, Izumizaki M, Homma I. Circadian changes in respiratory responses to acute hypoxia and histamine H1 receptors in mice. Adv Exp Med Biol. 2010;669:235-8.
Tani M, Onimaru H, Ikeda K, Kawakami K, Homma I. Menthol inhibits the respiratory rhythm in brainstem preparations of the newborn rats. Neuroreport. 2010 Dec 8;21(17):1095-9.
Fujii T, Onimaru H, Suganuma M, Homma I. Effects of hypocapnia on spontaneous burst activity in the piriform-amygdala complex of newborn rat brain preparations in vitro. Adv Exp Med Biol. 2010;669:333-6.
Onimaru H, Ikeda K, Kawakami K. Phox2b expressing neurons in the most rostral medulla of newborn rats. Adv Exp Med Biol. 2010;669:87-90.
Koiwa N, Masaoka Y, Kusumi T, Homma I. Sound localization difficulty affects early and late processing of auditory spatial information: investigation using the dipole tracing method. Clin Neurophysiol. 2010 Sep;121(9):1526-1539.
Masaoka Y, Satoh H, Akai L, Homma I. Expiration: the moment we experience retronasal olfaction in flavor. Neurosci Lett. 2010 Apr 5;473(2):92-6.
Masaoka Y, Homma I. Respiratory response toward olfactory stimuli might be an index for odor-induced emotion and recognition. Adv Exp Med Biol. 2010;669:347-52.
Tani M, Onimaru H, Ikeda K, Kawakami K, Homma I. Menthol inhibits the respiratory rhythm in brainstem preparations of the newborn rats. Neuroreport. 2010 Dec 8;21(17):1095-9.
Fujii T, Onimaru H, Suganuma M, Homma I. Effects of hypocapnia on spontaneous burst activity in the piriform-amygdala complex of newborn rat brain preparations in vitro. Adv Exp Med Biol. 2010;669:333-6.
Onimaru H, Ikeda K, Kawakami K. Phox2b expressing neurons in the most rostral medulla of newborn rats. Adv Exp Med Biol. 2010;669:87-90.
Koiwa N, Masaoka Y, Kusumi T, Homma I. Sound localization difficulty affects early and late processing of auditory spatial information: investigation using the dipole tracing method. Clin Neurophysiol. 2010 Sep;121(9):1526-1539.
Masaoka Y, Satoh H, Akai L, Homma I. Expiration: the moment we experience retronasal olfaction in flavor. Neurosci Lett. 2010 Apr 5;473(2):92-6.
Masaoka Y, Homma I. Respiratory response toward olfactory stimuli might be an index for odor-induced emotion and recognition. Adv Exp Med Biol. 2010;669:347-52.
2009年業績
《著書》
泉崎雅彦:呼吸困難について(COPD).現場の疑問に答える呼吸リハビリ徹底攻略 Q&A,15‐17,2009,中外医学社
泉崎雅彦:呼吸困難について(酸素飽和度).現場の疑問に答える呼吸リハビリ徹底攻略 Q&A,13‐14,2009,中外医学社
Homma I :Breathing and noh:Emotional breathing.New Frontiers in Respiratory Control.XI Annual Oxford Conference on Modeling and Control of Breathing,Homma I,Onimaru H,Fukuchi Y edi,337‐340,2009,Springer
Akai l,Ishizaki S,Matsuoka M,Homma I:Characteristics of respiratory pattern and anxiety in rhythmic gymnasts..New Frontiers in Respiratory Control.XI Annual Oxford Conference on Modeling and Control of Breathing,Homma I,Onimaru H,Fukuchi Y edi,329‐332,2009,Springer
Kanamaru M,Homma I:Chemical control of airway and ventilatory responses mediated via dorsomedial medullary 5-HT2 receptors.New Frontiers in Respiratory Control.XI Annual Oxford Conference on Modeling and Control of Breathing,Homma I,Onimaru H,Fukuchi Y edi,239‐242,2009,Springer
Iwase M,Ohshima Y,Izumizaki M,Homma I:Circadian changes in respiratory responses to acute hypoxia and histamine H1 receptors in mice.New Frontiers in Respiratory Control.XI Annual Oxford Conference on Modeling and Control of Breathing,Homma I,Onimaru H,Fukuchi Y edi,235‐238,2009,Springer
Fujii T,Onimaru H,Suganuma M,Homma I:Effects of hypocapnia on spontaneous burst activity in the piriform-amygdala complex of newborn rat brain preparation in vitro.New Frontiers in Respiratory Control.XI Annual Oxford Conference on Modeling and Control of Breathing,Homma I,Onimaru H,Fukuchi Y edi,333‐336,2009,Springer
Masaoka Y,Homma I:Respiratory response toward olfactory stimuli might be an index for odor-induced emotion and recognition..New Frontiers in Respiratory Control.XI Annual Oxford Conference on Modeling and Control of Breathing,Homma I,Onimaru H,Fukuchi Y edi,347‐352,2009,Springer
《訳書》
泉崎雅彦、本間生夫:呼吸系.オックスフォード生理学原書3版,349‐386,2009,丸善
本間生夫、泉崎雅彦:高所と潜水中での生理機能.オックスフォード生理学原書3版,647‐653,2009,丸善
《総説》
本間生夫,政岡ゆり:呼吸関連電位 -嗅覚?情動のメカニズム- .臨床脳波,51(4),234‐239,2009
泉崎雅彦:外呼吸の仕組み.呼吸器ケア,7(9),872‐876,890‐893,2009
政岡ゆり:香り豊かに暮らす—呼吸?嗅覚?情動の脳内関連の視点から—.心身健康科学,5(2),64‐69,2009
《原著論文》
Shimizu Y,Masaoka Y,Kawamura M,Homma I:Olfaction in Parkinson’s disease and aging.Showa Univ J Med Sci,21(2),131‐138,2009
Kanamaru M,Homma I:Dorsomedial medullary 5-HT2 receptors mediate immediate onset of initial hyperventilation,airway dilation and ventilatory decline during hypoxia in mice.Am J Physiol Regul Integr Comp Physiol,297(1),R34‐R41,2009
Ballanyi K,Ruangkittisakul A,Onimaru H.:Opioids prolong and anoxia shortens delay between onset of preinspiratory (pFRG) and inspiratory (preB?tC) network bursting in newborn rat brainstems.Pflugers Arch,458(3),571‐587,2009
Masaoka Y,Yajima H,Takayama M,Kawase A,Takakura N,Homma I:Typical dipole locations can be estimated using averaged somatosensory-evoked potentials and a standard brain model.J Physiol Sci,59(4),299‐305,2009
Onimaru H,Ikeda K,Kawakami K.:Phox2b,RTN/pFRG neurons and respiratory rhythmogenesis.Respir Physiol Neurobiol. 168(1-2),13‐8,2009
Onaka Y,Masaoka Y,Shimizu Y,Kawamura M,Homma I:Coherence and Source Localization of Parkinsonian Resting Tremor.Showa Univ J Med Sci,21(3),197‐202,2009
Sakurai S,Masaoka Y,Itabashi K,Homma I:Effects of trait anxiety on breathlessness and respiratory patterns during repeated breath-holds.Showa Univ J Med Sci,21(3),189‐196,2009
Minoura Y,Onimaru H,Iigaya K,Homma I,Kobayashi Y.:Electrophysiological responses of sympathetic preganglionic neurons to ANG II and aldosterone.Am J Physiol Regul Integr Comp Physiol.297(3),R699‐R706,2009
政岡ゆり:生きるための呼吸、感じる呼吸—香りの慣れ現象-.Cosmetoroly,17,112‐116,2009
泉崎雅彦:呼吸困難について(COPD).現場の疑問に答える呼吸リハビリ徹底攻略 Q&A,15‐17,2009,中外医学社
泉崎雅彦:呼吸困難について(酸素飽和度).現場の疑問に答える呼吸リハビリ徹底攻略 Q&A,13‐14,2009,中外医学社
Homma I :Breathing and noh:Emotional breathing.New Frontiers in Respiratory Control.XI Annual Oxford Conference on Modeling and Control of Breathing,Homma I,Onimaru H,Fukuchi Y edi,337‐340,2009,Springer
Akai l,Ishizaki S,Matsuoka M,Homma I:Characteristics of respiratory pattern and anxiety in rhythmic gymnasts..New Frontiers in Respiratory Control.XI Annual Oxford Conference on Modeling and Control of Breathing,Homma I,Onimaru H,Fukuchi Y edi,329‐332,2009,Springer
Kanamaru M,Homma I:Chemical control of airway and ventilatory responses mediated via dorsomedial medullary 5-HT2 receptors.New Frontiers in Respiratory Control.XI Annual Oxford Conference on Modeling and Control of Breathing,Homma I,Onimaru H,Fukuchi Y edi,239‐242,2009,Springer
Iwase M,Ohshima Y,Izumizaki M,Homma I:Circadian changes in respiratory responses to acute hypoxia and histamine H1 receptors in mice.New Frontiers in Respiratory Control.XI Annual Oxford Conference on Modeling and Control of Breathing,Homma I,Onimaru H,Fukuchi Y edi,235‐238,2009,Springer
Fujii T,Onimaru H,Suganuma M,Homma I:Effects of hypocapnia on spontaneous burst activity in the piriform-amygdala complex of newborn rat brain preparation in vitro.New Frontiers in Respiratory Control.XI Annual Oxford Conference on Modeling and Control of Breathing,Homma I,Onimaru H,Fukuchi Y edi,333‐336,2009,Springer
Masaoka Y,Homma I:Respiratory response toward olfactory stimuli might be an index for odor-induced emotion and recognition..New Frontiers in Respiratory Control.XI Annual Oxford Conference on Modeling and Control of Breathing,Homma I,Onimaru H,Fukuchi Y edi,347‐352,2009,Springer
《訳書》
泉崎雅彦、本間生夫:呼吸系.オックスフォード生理学原書3版,349‐386,2009,丸善
本間生夫、泉崎雅彦:高所と潜水中での生理機能.オックスフォード生理学原書3版,647‐653,2009,丸善
《総説》
本間生夫,政岡ゆり:呼吸関連電位 -嗅覚?情動のメカニズム- .臨床脳波,51(4),234‐239,2009
泉崎雅彦:外呼吸の仕組み.呼吸器ケア,7(9),872‐876,890‐893,2009
政岡ゆり:香り豊かに暮らす—呼吸?嗅覚?情動の脳内関連の視点から—.心身健康科学,5(2),64‐69,2009
《原著論文》
Shimizu Y,Masaoka Y,Kawamura M,Homma I:Olfaction in Parkinson’s disease and aging.Showa Univ J Med Sci,21(2),131‐138,2009
Kanamaru M,Homma I:Dorsomedial medullary 5-HT2 receptors mediate immediate onset of initial hyperventilation,airway dilation and ventilatory decline during hypoxia in mice.Am J Physiol Regul Integr Comp Physiol,297(1),R34‐R41,2009
Ballanyi K,Ruangkittisakul A,Onimaru H.:Opioids prolong and anoxia shortens delay between onset of preinspiratory (pFRG) and inspiratory (preB?tC) network bursting in newborn rat brainstems.Pflugers Arch,458(3),571‐587,2009
Masaoka Y,Yajima H,Takayama M,Kawase A,Takakura N,Homma I:Typical dipole locations can be estimated using averaged somatosensory-evoked potentials and a standard brain model.J Physiol Sci,59(4),299‐305,2009
Onimaru H,Ikeda K,Kawakami K.:Phox2b,RTN/pFRG neurons and respiratory rhythmogenesis.Respir Physiol Neurobiol. 168(1-2),13‐8,2009
Onaka Y,Masaoka Y,Shimizu Y,Kawamura M,Homma I:Coherence and Source Localization of Parkinsonian Resting Tremor.Showa Univ J Med Sci,21(3),197‐202,2009
Sakurai S,Masaoka Y,Itabashi K,Homma I:Effects of trait anxiety on breathlessness and respiratory patterns during repeated breath-holds.Showa Univ J Med Sci,21(3),189‐196,2009
Minoura Y,Onimaru H,Iigaya K,Homma I,Kobayashi Y.:Electrophysiological responses of sympathetic preganglionic neurons to ANG II and aldosterone.Am J Physiol Regul Integr Comp Physiol.297(3),R699‐R706,2009
政岡ゆり:生きるための呼吸、感じる呼吸—香りの慣れ現象-.Cosmetoroly,17,112‐116,2009
2008年業績
著書
Onimaru H, Homma I. Two Modes of Respiratory Rhythm Generation in the Newborn Rat Brainstem-Spinal Cord Preparation. In Advances in Experimental Medicine and Biology Series. Eds: M.J. Poulin and R.J.A. Wilson. Springer Publishers, New York. Volume 605:104-108, 2008泉崎雅彦(共著): 呼吸困難感のメカニズム. 改訂版リハ実践テクニック呼吸ケア,2-7,メジカルビュー、2008
原著論文
Inoue M, Masaoka Y, Kawamura M, Okamoto Y, Homma I. Differences in areas of human frontal medial wall activated by left and right motor execution: Dipole-tracing analysis of grand-averaged potentials incorporated with MNI three-layer head model. Neurosci Lett 437:82-87,2008Ohshima Y, Iwase M, Izumizaki M, Kanamaru M, Homma I. Time-dependent ventilatory response to poikilocapnic hypoxia during light and dark periods and the role of histamine H1 receptors in mice. J Physiol Sci 58:147-150,2008
Masaoka Y, Satoh H, Kawamura M, Homma I. Respiratory responses to olfactory stimuli in Parkinson's disease. Resp Physiol Neurobiol 161:136-141,2008
Izumizaki M, Nakajima T, Iwase M, Ohshima Y, Homma I. Effect of thixotropy conditioning of inspiratory muscles on the chest wall response to CPAP. Respirology 13: 379-386,2008
Enkhjargal B, Hashimoto M, Kinoshita H, Sakai Y.Characterization of contractile activity in the renal artery of ovariectomized rats.J Smooth Muscle Res 44:17-28, 2008
Onimaru H, Ikeda K, and Kawakami K. CO2-Sensitive Preinspiratory Neurons of the Parafacial Respiratory Group Express Phox2b in the Neonatal Rat. J Neurosci. 28(48):12845–12850, 2008
OSHIMA N, KUMAGAI H, ONIMARU H, KAWAI A, PILOWSKY P M,IIGAYA K, TAKIMOTO C, HAYASHI K, SARUTA T, and ITOH H. Monosynaptic Excitatory Connection from the RostralVentrolateral Medulla to Sympathetic Preganglionic Neurons Revealed by Simultaneous Recordings To directly investigate whether a monosynaptic connection exists between neurons in the rostral ventrolateral. Hypertens Res. 31: 1445–1454, 2008
2007年業績
著書
本間生夫(共著):呼吸困難、包括的呼吸リハビリテーション、塩谷隆信 編、110-118、新興医学出版社、東京、2007本間生夫(共著):環境における呼吸の適応、標準生理学、医学書院、東京、2007
原著論文
Iwase M, Izumizaki M, Miyamoto K, Ishiguro T, Kanamaru M, Homma I. Lack of histamine type-1 receptors impairs the thermal response of respiration during hypoxia in mice (Mus musculus). Comp Biochem Physiol A Mol Integr Physiol 146: 242-251, 2007.Iigaya K, Kumagai H, Onimaru H, Kawai A, Oshima N, Onami T, Takimoto C, Kamayachi T, Hayashi K, Saruta T, Itoh H. Novel axonal projection from the caudal end of the ventrolateral medulla to the intermediolateral cell column. Am J Physiol Regul Integr Comp Physiol. 292: R927-36, 2007.
Masaoka Y, Yoshimura N, Inoue M, Kawamura M, Homma I.Impairment of odor recognition in Parkinson's disease caused by weak activations of the orbitofrontal cortex. Neurosci Lett. Jan 22;412(1):45-50, 2007.
Takakura N, Yajima H. A double-blind placebo needle for acupuncture research. BMC Complement Alteen Med, 7:31,2007
Kanamaru M, Homma I.
Compensatory airway dilation and additive ventilatory augmentation mediated by dorsomedial medullary 5-hydroxytryptamine 2 receptor activity and hypercapnia. Am J Physiol Regul Integr Comp Physiol, 293:R854-860,2007
Ohshima Y, Iwase M, Izumizaki M, Ishiguro T, Kanamaru M, Nakayama H, Gejyo F, Homma I. Hypoxic ventilatory response during light and dark periods and the involvement of histamine H1 receptor in mice. Am J Physiol Regul Integr Comp Physiol, 293(3):R1350-1356, 2007
Onimaru H, Ikeda K, Kawakami K. Defective interaction between dual oscillators for respiratory rhythm generation in Na+, K+-ATPase α2 subunit-deficient mice. J Physiol 584.1: 271‐284, 2007.
Masaoka Y, Onaka Y, Shimizu Y, Sakurai S, Homma I.
State anxiety dependent on perspiration during mental stress and deep inspiration.
J Physiol Sci,57(2):121-126. 2007
Onimaru H, Homma I. Spontaneous Oscillatory Burst Activity in the Piriform-Amygdala Region and its Relation to In Vitro Respiratory Activity in Newborn Rats. Neurosci. 144: 387?394, 2007.
Koyama S, Tachibana N, Masaoka Y, Homma I, Kawamura M. Decreased myocardial (123)I-MIBG uptake and impaired facial expression recognition in a patient with REM sleep behavior disorder. Mov Disord,22(5):746-747,2007
Sekihara C, Izumizaki M, Yasuda T, Nakajima T, Atsumi T, Homma I. Effect of cooling on thixotropic position sense error in human biceps muscle. Muscle Nerve, 35,781-787,2007
総説
本間生夫?田中一正:呼吸リハビリテーションの生理的背景.呼吸、レスピレーションリサーチファンデーション、26(11):981-989、2007政岡ゆり?本間生夫:香りと呼吸の脳内メカニズム-生きる呼吸、香る呼吸、思う呼吸-.Aroma Research,8(3):218-223,2007
政岡ゆり?本間生夫:呼吸からみた嗅覚の生理学、神経内科、66(4):322-331、2007
泉崎雅彦: 呼吸困難感と呼吸筋シクソトロピー. 呼吸器科,11,302-310,2007
2006年業績
著書
Onimaru H, Arata A, Arata S, Homma I Visualization of respiratory neuron activity in the ventral medulla from a newborn rodent. Breathing, Feeding, and Neuroprotection, Ed by Homma I and Shioda S, Springer-Verlag Tokyo, pp 3-11, 2006.Arata S, Onimaru H, Arata A, Homma I, Inoue T, Shioda S, Shirasawa S, Cleary ML Search for genes involved central respiratory failure using mice models. Breathing, Feeding, and Neuroprotection Ed by Homma I and Shioda S Springer-Verlag Tokyo, pp 12-16, 2006.
Iwase M, Izumizaki M, Miyamoto K, Kanamaru M, Homma I Control of central histaminergic neurons for respiration during hypercapnia in conscious mice. Breathing, Feeding, and Neuroprotection Ed by Homma I and Shioda S Springer-Verlag Tokyo, pp17-24, 2006
Masaoka Y, Homma I. Can not live without breathing, without emotions. Breathing, Feeding, and Neuroprotection Ed by Homma I and Shioda S Springer-Verlag Tokyo, pp115-124, 2006
Homma I, Masaoka Y, Umewaka N. Breathing mind in ‘Noh’. Breathing, Feeding, and Neuroprotection Ed by Homma I and Shioda S Springer-Verlag Tokyo, pp125-134, 2006
Shinoda J, Nakagome K, Mimura M, Homma I. Source localization of event-related potentials related to cross-modal semantic interference effect using scalp-skull-brain dipole tracing method. Breathing, Feeding, and Neuroprotection Ed by Homma I and Shioda S Springer-Verlag Tokyo, pp139-146, 2006
鬼丸洋(分担執筆)胎児の呼吸中枢, 呼吸の辞典:11.朝倉書店,東京, 119-134, 2006
泉崎雅彦(分担執筆):喘ぎ、呼吸の辞典、朝倉書店、東京、556-562、2006
原著論文
Izumizaki M, Iwase M, Ohshima Y, Homma I. Acute effects of thixotropy conditioning of inspiratory muscles on end-expiratory chest wall and lung volumes in normal humans. J Appl Physiol 101: 298-306, 2006.Izumizaki M, Ohshima Y, Iwase M, Homma I. Chest wall motion after thixotropy conditioning of inspiratory muscles in healthy humans. J Physiol Sci 56: 433-440, 2006.
Ishiguro T, Iwase M, Kanamaru M, Izumizaki M, Ohshima Y, Homma I. Contribution of histamine type-1 receptor to metabolic and behavioral control of ventilation. J Physiol Sci 56: 287-295, 2006.
Ishiguro T, Iwase M, Kanamaru M, Izumizaki M, Ohshima Y, Homma I. Impaired ventilation and metabolism response to hypoxia in histamine H1 receptor-knockout mice. Respir Physiol Neurobiol 154: 331-341, 2006.
Miyamoto K, Iwase M, Nyui M, Arata S, Sakai Y, Gabazza EC, Kimura H, Homma I. Histamine type 1 receptor deficiency reduces airway inflammation in a murine asthma model. Int Arch Allergy Immunol 140: 215-222, 2006.
Izumizaki M, Kakizaki F, Tanaka K, Homma I. Immediate effects of thixotropy conditioning on chest wall volume in chronic obstructive pulmonary disease. Respir Care, 51 :750-757,2006
Onimaru H, Kumagawa Y, Homma I. Respiration-related rhythmic activity in the rostral medulla of newborn rats. J Neurophysiol. 96: 55-61, 2006.
Kawai A, Onimaru H, Homma I. Mechanisms of CO2/H+ chemoreception by respiratory rhythm generator neurons in the medulla from newborn rats in vitro. J Physiol.572:525-537, 2006.
総説
本間生夫?政岡ゆり:呼吸と脳、臨床生理学、34、1(Suppl)、10-19、2006本間生夫:呼吸筋からみた呼吸療法、臨床麻酔、30、7:1071-1078、真興交易、東京、2006
政岡ゆり?河村満?井上学?本間生夫:パーキンソン病の嗅覚障害 脳と神経 VOL.58, No9:731-737, 2006
Onimaru H, Homma I, Feldman JL, Janczewski WA. The para-facial respiratory group (pFRG)/ pre Botzinger Complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. J Appl Physiol. 100: 2094-2095, 2006.